TABLE 3.

Susceptibilities of aerobic bacteria to tigecycline and tetracycline

Species (na)bMIC of drug (μg/ml)
TigecyclineTetracycline
Range50%90%Range50%90%
All strains combined (2,490)0.015-320.2520.015->322>32
Gram-positive strains
    All streptococci combined (269)0.03-0.250.060.120.12->320.5>32
        S. agalactiae (20)0.06-0.060.060.060.25->3232>32
        S. pneumoniae, penicillin-S (23)0.03-0.120.060.060.12-0.50.250.5
        S. pneumoniae, penicillin-I (100)0.03-0.250.060.120.12->320.25>32
        S. pneumoniae, penicillin-R (86)0.03-0.250.060.120.25->323232
        S. pyogenes (40)0.03-0.060.060.060.12-320.2516
    All staphylococci combined (130)0.06-20.120.250.12->320.25>32
        All S. aureus strains combined (44)0.12-10.120.50.25->320.25>32
        S. aureus, methicillin-R (24)0.12-10.120.250.25->320.25>32
        S. aureus, methicillin-S (20)0.12-0.250.120.120.25->320.250.5
    All coagulase-negative staphylococci combined (86)0.06-20.120.50.12->321>32
        S. epidermidis, methicillin-R (21)0.06-0.50.120.50.25->32232
        S. epidermidis, methicillin-S (35)0.06-10.120.50.12->321>32
        S. haemolyticus (30)0.06-20.250.50.12->320.5>32
    All enterococci combined (216)0.015-0.250.120.250.015->322>32
        E. avium (40)0.015-0.250.120.120.015->3216>32
        E. casseliflavus (23)0.12-0.250.120.250.25-32132
        E. faecalis, vancomycin-R (34)0.06-250.120.250.25->321>32
        E. faecalis, vancomycin-S (19)0.12-250.120.251->3232>32
        E. faecium, vancomycin-R (20)0.06-0.250.120.120.25->3216>32
        E. faecium, vancomycin-S (40)0.06-0.250.120.120.12->320.5>32
        E. gallinarium (40)0.06-0.250.120.250.25->321>32
    Listeria monocytogenes (100)0.06-0.120.120.120.25->3211
Gram-negative strains
    Moraxella catarrhalis (64)0.06-0.250.060.120.06-160.250.5
    Neisseria meningitidis (93)0.03-0.50.120.250.03-10.250.5
    All Haemophilus spp. combined (113)0.12-10.250.50.25->320.52
        H. influenzae (64)0.12-10.250.50.25-320.50.5
        H. parainfluenzae (49)0.12-10.510.25->320.58
    All Enterobacteriaceae combined (1,352)0.06-160.520.25->3216>32
        Citrobacter freundii (20)0.12-20.250.50.5->3212
        Citrobacter. koseri (41)0.12-10.250.251-411
        Enterobacter aerogenes (21)0.25-10.511->322>32
        Enterobacter cloacae (20)0.25-0.50.50.51-222
        Escherichia coli (20)0.12-0.50.250.51->322>32
        Escherichia coli, ESBL+ (20)0.25-10.250.51->32>32>32
        Klebsiella oxytoca (19)0.25-20.521-814
        Klebsiella pneumoniae (20)0.5-20.511-824
        Klebsiella pneumoniae, ESBL+ (36)0.25-4121->32>32>32
        Morganella morganii (20)1-8442->32>32>32
        Proteus mirabilis (20)1-42432->32>32>32
        Providencia rettgeri (100)0.25-16441->3232>32
        Providencia stuartii (98)0.25-8242->32>32>32
        Proteus vulgaris (60)0.5-2121->32832
        Shigella boydii (106)0.12-10.250.50.25->32>32>32
        Shigella dysenteriae (92)0.12-10.250.251->32>32>32
        Shigella flexneri (100)0.06-10.250.250.5->32>32>32
        Shigella sonnei (103)0.12-10.250.50.5->32>32>32
        Salmonella enterica
            Serovar Enteritidis (100)0.12-20.510.5->321>32
            Serovar Paratyphi (111)0.12-20.510.5->32132
            Serovar Typhi (105)0.06-10.250.50.25->3214
            Serovar Typhimurium (100)0.25-2121->32>32>32
        Serratia marcescens (20)1-4128->3216>32
    All non-Enterobacteriaceae combined (153)0.06-320.580.12->324>32
        All Acinetobacter spp. (41)0.12-40.520.25->3228
        Burkholderia cepacia (32)0.06-16180.12->32>32>32
        Pseudomonas aeruginosa (20)8-32161616->3232>32
        Pasteurella multocida (40)0.06-0.250.060.250.12-32116
        Stenotrophomonas maltophilia (20)0.06-8140.25-32832
  • a n, no. of strains.

  • b S, sensitive; I, intermediate; R, resistant.