TABLE 1.

Performance of susceptibility testing methods for detecting KPC-mediated resistance

MethodSensitivity (%)/specificity (%) of:
Intermediate or resistant susceptibility resultaCarbapenem MIC of >1 μg/ml
MeropenemImipenemErtapenemMeropenemImipenemErtapenem
Reference BMD94/9894/9397/89100/93100/93100/89
Etest58/9655/9690/8484/9190/89100/84
Disk diffusion71/9642/9697/87NAbNANA
Vitek Legacy52/9855/96NAdNAcNAcNAd
Vitek 248/9671/9694/9371/9394/8994/89
MicroScan84/9874/96100/89100/93100/93NAc
Phoenix61/9881/96NAd74/9687/93NAd
Sensititre42/9829/96NAd81/96NAcNAd
  • a Interpretive criteria were based upon CLSI criteria.

  • b NA, not applicable.

  • c Not applicable because the MIC range tested was not low enough (e.g., lowest dilution tested was either 2 μg/ml or 4 μg/ml) for the identification of a carbapenem MIC of >1 μg/ml.

  • d Not applicable because ertapenem was not available on a panel.