TABLE 2.

In vitro susceptibilities of 2,656 clinical isolates of Candida spp. to micafungin and caspofungin

Organism (no. of isolates tested) and antifungal agentCumulative % susceptible at a MIC (μg/ml) ofa:
0.0070.0150.030.060.120.250.51248
C. albicans (1,476)
    Micafungin107695>99>99100
    Caspofungin2286898>99>99100
C. glabrata (356)
    Micafungin491969899>99>99100
    Caspofungin95796989999>99>99>99100
C. tropicalis (269)
    Micafungin22870949999>99100
    Caspofungin1287397989999>99>99>99>99
C. krusei (63)
    Micafungin3168698100
    Caspofungin2251719298100
C. kefyr (17)
    Micafungin41100
    Caspofungin1294100
C. parapsilosis (383)
    Micafungin111152176100
    Caspofungin1148478898>99100
C. guilliermondii (45)
    Micafungin29185898100
    Caspofungin2514418193939395
C. lusitaniae (24)
    Micafungin867100
    Caspofungin445892100
Candida spp. (23)
    Micafungin4263535527891100
    Caspofungin132239488396100
Total (2,656)
    Micafungin657748183848896100
    Caspofungin1205480839198>99>99>99>99
  • a Broth microdilution testing was performed according to CLSI M27-A2 (8), using 24-h incubation and a MIC-2 endpoint.