TABLE 2.

Frequency distribution of clinical, epidemiological, and genotypes of plcD gene among seven RD genotypes by Fisher's exact testa

CharacteristicsNo. (%) of isolates in each RD genotype-defined subgroupbP
1234567
Site of disease0.0454
    Thoracic526 (89.2)16 (88.9)10 (76.9)2 (40.0)11 (84.6)8 (100.0)1 (100.0)
    Extrathoracic64 (10.8)2 (11.1)3 (23.1)3 (60.0)2 (15.4)0 (0.0)0 (0.0)
Race/ethnicity<0.0001
    Non-Hispanic white336 (57.0)3 (16.7)7 (53.8)0 (0.0)8 (61.5)6 (75.0)0 (0.0)
    Non-Hispanic black216 (36.6)0 (0.0)4 (30.8)1 (20.0)3 (23.1)1 (12.5)0 (0.0)
    Hispanic25 (4.2)0 (0.0)1 (7.7)0 (0.0)0 (0.0)0 (0.0)1 (100.0)
    Asian/Pacific Islander10 (1.7)15 (83.3)1 (7.7)4 (80.0)2 (15.4)1 (12.5)0 (0.0)
    American Indian3 (0.5)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)
Age (yr)0.0004
    0-146 (1.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)
    15-2415 (2.5)2 (11.1)1 (7.7)1 (20.0)1 (7.7)0 (0.0)0 (0.0)
    25-44120 (20.3)5 (27.8)5 (38.5)3 (60.0)4 (30.8)2 (25.0)0 (0.0)
    45-64138 (23.4)8 (44.4)6 (46.2)1 (20.0)4 (30.8)4 (50.0)0 (0.0)
    65+311 (52.7)3 (16.7)1 (7.7)0 (0.0)4 (30.8)2 (25.0)1 (100.0)
plcD genotype<0.0001
    Wild type392 (66.4)17 (94.4)7 (53.8)1 (20.0)4 (30.8)1 (12.5)1 (100.0)
    plcD mutation35 (5.9)1 (5.6)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)
    plcD and adjacent genes mutation163 (27.6)0 (0.0)6 (46.2)4 (80.0)9 (69.2)7 (87.5)0 (0.0)
  • a Data are for 648 isolates. The variables without a statistically significant difference in the frequency distribution among seven genetic groups are not listed in this table. They include gender, city of residence, residence in a long-term-care facility, residence in a correctional facility, injection drug use, non-injection-drug use, excessive alcohol use, cavitary lung disease, and sputum smear positivity.

  • b Subgroup 1, no deletion of RDs; subgroup 2, RD239 deletion; subgroup 3, concurrent deletion of RD105, RD181, and RD142; subgroup 4, concurrent deletion of RD105, RD181, and RD150; subgroup 5, concurrent deletion of RD105 and RD181; subgroup 6, RD105 deletion only; and subgroup 7, partial deletion of RD105.