TABLE 5.

Fluoroquinolones usage levels between 1999 and 2004 and antimicrobial resistance among GNB between 1999 and 2004a

OrganismR2 values for fluoroquinolone resistance compared to that of antimicrobials shown
J01MLevofloxacinCiprofloxacinGatifloxacinMoxifloxacin
P. aeruginosa0.73520.66240.18060.64730.1588
E. coli0.75520.72620.58460.50990.6468
K. pneumoniae0.55440.61930.61350.18160.07451
E. cloacae0.50480.58520.09680.22240.0173
Acinetobacter spp.0.58440.67240.66020.19760.6711
S. marcescens0.17580.12120.43360.20230.566
E. aerogenes0.0914−0.0338−0.14010.3243−0.1359
P. mirabilis0.05560.14840.0879−0.18760.2782
K. oxytoca−0.0721−0.1682−0.03070.04150.2849
C. freundii0.44620.24550.14630.65280.3016
  • a Adjusted linear regression values comparing antimicrobial usage levels of fluoroquinolones in the United States between 1999 and 2004 and rates of antimicrobial resistance among GNB between 1999 and 2004. J01M, antimicrobial class of fluoroquinolones.