TABLE 2.

PCR assay results from a combined cohort of 264 subjects analyzing the utility of each assay for the diagnosis of BV, with Amsel clinical criteria used to define BVa

BacteriumSensitivity (%) (95% CI)Specificity (%) (95% CI)OR (95% CI)
BVAB143.2 (33.0-54.1)96.7 (93.0-98.5)22.45 (8.90-56.6)
BVAB286.4 (77.3-92.2)92.9 (88.2-95.8)83.2 (35.6-195)
BVAB342.0 (31.8-52.9)96.7 (93.0-98.5)21.3 (8.5-53.9)
G. vaginalis 96.3 (89.7-98.7)29.5 (23.4-36.5)10.9 (3.3-36.0)
Atopobium spp.96.3 (89.7-98.7)77.05 (70.4-82.6)87.3 (26.2-291)
Eggerthella-like bacterium91.4 (83.2-95.8)86.3 (80.6-90.6)66.8 (27.65-162)
Leptotrichia spp.82.7 (73.1-89.4)89.1 (83.7-92.8)39.0 (18.6-81.7)
Megasphaera phylotype 195.1 (88.0-98.1)88.5 (83.1-92.4)148.5 (49.3-448)
Megasphaera phylotype 218.5 (11.6-28.3)98.9 (96.1-99.7)20.6 (4.6-92.4)
Either Megasphaera sp.97.5 (91.4-99.3)88.5 (83.1-92.4)305 (69.7-1,332)
BVAB-TM733.3 (24.0-44.2)97.8 (94.5-99.2)22.4 (7.5-66.8)
M. curtisii 55.6 (44.7-65.9)92.9 (88.2-95.8)16.3 (8.0-33.4)
M. mulieris 22.2 (14.5-32.4)100 (97.9-100)Infinity
Either Mobiluncus sp.65.4 (54.6-74.9)92.9 (88.2-95.8)24.8 (12.0-51.2)
Peptoniphilus sp. type 183.8 (74.1-90.3)70.0 (63.0-76.1)12.0 (6.1-23.5)
Peptoniphilus lacrimalis 70.4 (59.7-79.2)78.1 (71.6-83.5)8.5 (4.7-15.4)
Either Peptoniphilus sp.88.9 (80.2-94.0)60.7 (53.4-67.4)12.3 (5.8-26.2)
Prevotella G163.8 (52.8-73.4)94.0 (89.6-96.6)27.5 (12.9-58.9)
L. crispatus 16.1 (9.6-25.6)10.4 (6.8-15.7)0.022 (0.01-0.05)
L. iners 98.8 (93.3-99.8)8.8 (5.5-13.7)7.7 (1.0-58.8)
Either BVAB1 or BVAB287.7 (78.7-93.2)92.9 (88.2-95.8)92.8 (38.9-222)
Either BVAB1 or BVAB348.2 (37.6-58.9)95.1 (90.9-97.4)18.0 (8.1-39.9)
Either BVAB2 or BVAB387.7 (78.7-93.2)92.9 (88.2-95.8)92.8 (38.9-222)
Either BVAB1, -2, or -387.7 (78.7-93.2)92.9 (88.2-95.8)92.8 (38.9-222)
Either Megasphaera phylotype 1 or BVAB298.8 (93.3-99.8)88.5 (83.1-92.4)617 (81.6-4,670)
  • a The analysis consisted of 81 subjects with BV and 183 subjects without BV.