TABLE 2.

Regional differences in specificities and sensitivities based on a defined cutoffa

AntigenNorthern IrelandArgentinaMexicoCombined
Specificity (%)Sensitivity (%)Specificity (%)Sensitivity (%)Specificity (%)Sensitivity (%)Specificity (%)Sensitivity (%)
PPDA3586618189655578
PPDB4591787589906684
ESAT6100597894100409169
CFP1010050899189509468
PE13100231007889109843
MPB709036835610058936
TB10.4100459450NDdND97b48b
PE5100278956100259639
TB27.410014567210058336
ESAT6 + CFP10c100739494NDND97b85b
  • a Specificity and sensitivity are based on cutoff values calculated as two times the ODI for each antigen and country. Only data from confirmed cases were used. Comfirmatory assays were lesion analysis, bacterial culture, or PCR analysis. n = 22 for Northern Ireland, n = 34 for Argentina, and n = 21 for Mexico.

  • b Based only on data from Northern Ireland and Argentina.

  • c The ESAT6 and CFP10 antigens were tested together in the same well (one-well assay).

  • d ND, not determined.