TABLE 3.

Parameters of locus variability among geographically diverse isolates

Isolate group and locusaSubsetdAllelic diversityAllele no.No. of repeats (range)
90 isolatesb
    QUB-2163b10.84102-11
    QUB-2610.8392-12
    MIRU 1010.7972-8
    ETR A10.7892-10
    VNTR 195510.74101-14
    MIRU 2610.7281-8
    MIRU 4010.7171-8
    ETR C10.7152-6
    MIRU 3110.761-6
    QUB-415610.750-4
    MIRU 2320.6891-11
    VNTR 042410.6680-8
    VNTR 369010.6471-8
    VNTR 240110.6141-4
    ETR B20.5851-5
    MIRU 0410.5591-6
    VNTR 234720.5242-5
    MIRU 1610.4841-4
    MIRU 3920.4141-4
    MIRU 2420.3931-6
    VNTR 317120.3551-5
    MIRU 2020.221-2
    MIRU 2720.232-4
    MIRU 0220.131-3
    QUB-3232Excluded0.92210-24
    QUB-3336Excluded0.91182-21
    QUB-18Excluded0.87122-16
    QUB-2163aExcluded0.87141-29
    QUB-1895Excluded0.6561-7
494 isolatesc
    QUB-2610.84
    QUB-2163b10.82
    VNTR 195510.76
    MIRU 2610.75
    ETR A10.75
    MIRU 1010.74
    MIRU 4010.73
    MIRU 3110.72
    VNTR 042410.71
    ETR C10.69
    VNTR 369010.69
    QUB-415610.67
    MIRU 2320.65
    VNTR 240110.62
    MIRU 1610.53
    VNTR 234710.48
    MIRU 3920.45
    ETR B20.44
    MIRU 0410.38
    MIRU 2420.35
    MIRU 2020.30
    VNTR 317120.27
    MIRU 2720.25
    MIRU 0220.16
  • a Loci are listed within each isolate group in descending order of allelic diversity, except for those loci that were excluded.

  • b Standardized worldwide collection from reference 23.

  • c Extended collection with isolates from worldwide origins, including the 90 isolates from reference 23. Because of their particular population structure, characterized by homogeneous clonal groups with horizontal gene transfers among them (15), M. prototuberculosis isolates were not considered for this analysis.

  • d 1, discriminatory subset of 15 loci; 2, subset of nine auxiliary loci. Table 1 gives alias designations of loci.