TABLE 2.

Demographic, clinical, and laboratory information for the 24 HHV-6-positive patientsa

Patient no.Sample typePatientDays between onset and collectionDiagnosisSymptom(s)CSF informationHHV-6 real-time PCR CT valueHHV-6 typing resultTyping primer usedOther agents detected
SexAge (yr)CSF abnormalityProtein level (mg/dl)WBC count% Lymphs
1CSFM1210EncephalitisFever, altered mental status, hallucinationsYes56359531.78BU86
2CSFF122EncephalitisFever, altered mental statusNo334Unknown31.98BU86
3CSFF27EncephalitisFever, altered mental status, seizures, muscle weaknessUnknownUnknownUnknownUnknown36.07UntypedU86
4CSFM45UnknownEncephalitisFever, headache, seizures, altered mental status, muscle weakness, muscle painYesUnknown208034.3UntypedU86
5CSFM21EncephalitisFever, seizures, altered mental statusNo160Unknown39.3BU95
6CSFF10UnknownFever, rash, altered mental status, increased AST/ALTYes48325038.65UntypedU86
7CSFM20MeningitisFever, altered mental status, coughUnknown28UnknownUnknown36.5BU86
8CSFF3031Encephalitis; acute onset psychosisHeadache, rash, altered mental status, confusion, hyperactivityYes131010032.29BU95
9CSFM8UnknownEncephalitisSeizures, altered mental status, muscle weakness, stiff neckYes35589037.58BU95
10CSFM3814EncephalitisFever, altered mental status, headache, stiff neckYesUnknownUnknownUnknown39.74UntypedU95EBV+ve
11CSFF1UnknownEncephalitisSeizuresUnknownUnknownUnknownUnknown33.3BU95
12CSF/autopsyM2UnknownEncephalitis; meningitisSeizuresUnknownUnknownUnknownUnknown38.47BU95
13CSFM171MeningitisHeadache, stiff neck, muscle weakness, muscle painYes150402925.03BU95
14CSFF815EncephalitisFever, headache, rash, altered mental statusUnknownUnknownUnknownUnknown33.56UntypedU95
15CSFF40EncephalitisFever, seizures, altered mental statusNo252034.75BU95
16CSFF83MeningitisFever, headache, stiff neck, meningeal signYes662285839.92BU95
17Liver tissueF307UnknownFever, rash, elevated LFT result, jaundice, pruritisN/AN/AN/AN/A34BU95
18CSFM601MeningoencephalitisFever, seizures, altered mental statusYes4999N/A28.89BU95
19CSFM251MeningitisMuscle weaknessYes1194910028.68BU95
20CSF/autopsyF1UnknownUnknownSickle cell disease, anemia, feverUnknownUnknownUnknownUnknown37.96BU95Adv+ve
21CSF/autopsyM2UnknownUnknownFever, cough, bronchiolitis symptomsUnknownUnknownUnknownUnknown37.35BU95
22CSFM718EncephalitisFever, altered mental statusYes1174710029.62UntypedU95EBV+ve
23ACSFF316Encephalitis; cerebellitisMuscle weakness, ataxiaUnknownUnknownUnknownUnknown32.2BU95
23BSerum27UnknownN/AN/AN/AN/A30.7BU95
23CCSF34Headache, altered mental status, vomiting, tremorNo151Unknown36.09BU95
24CSFM12EncephalitisFever, muscle weakness, altered mental status, seizures, rashYes28856532.9BU95
  • a F, female; M, male; AST/ALT, alanine aminotransferase/aspartate aminotransferase; LFT, liver function test; % Lymphs, number of lymphocytes as a percentage of total WBC count; N/A, not applicable; Adv, adenovirus. U86 and U95 are the genes targeted in the HHV-6 PCR typing assays. Three specimens were tested for patient 23 (A, B, and C).