TABLE 2.

Occurrence and frequency of the various drug resistance mutations (per codon) by sequence analysis and LiPA

AssayMutation(s) at codon:Frequency (no. of mutants)
80173180181204236BaselineWk 12Wk 24Wk 52Wk 156
SequencingM204I111
L180MM204I1
L180MM204I, M204V2
L80IM204I1371
L80IL180MM204I1
L80IL180MM204I, M204V2
L80IV173LM204I1
L80VM204I1
L80VL180MM204I1
L80IL180MM204V1
V173LL180MM204V1
L80I1
A181T121
N236T1
    Total1261211
LiPAM204I333
L180MM204I
L180MM204I, M204V1
L80IM204I1231
L80IL180MM204I1
L80IL180MM204I, M204V1
L80IV173LM204I1
L80VM204I
L80VL180MM204I
L80IL180MM204V
V173LL180MM204V
L80I
A181T3542
N236T1
L80IM204I, M204V1
L80I, L80VM204I111
L80I, L80VA181TM204I, M204VN236T1
L80I, L80VL180MM204I, M204VN236T111
L180MA181TM204IN236T1
A181TM204I13
L80VL180MA181TM204V1
L80VA181T2
L80VM204I, M204V1
L80VL180MM204I, M204V11
M204I, M204V11
V173LL180MM204I, M204V1
L80IV173LL180MM204V1
M204V112
L80IM204IN236T1
L180MM204V1
L80I, L80VL180MM204I, M204V11
L80IA181TM204I, M204V1
L80I, L80VL180MM204I1
L80IL180MA181TM204I1
    Total310172514