TABLE 3.

Variation in echinocandin MIC profiles by geographic region

Region(s) and speciesNo. of isolates testedAntifungal agentNo. of isolates for which the MIC (μg/ml) was:
0.0070.0150.030.060.120.250.5124≥8
Asia-Pacific
    C. albicans547Anidulafungin3213619512849412
Caspofungin121392281481631
Micafungin633511082122
    C. parapsilosis153Anidulafungin11544966
Caspofungin169655598
Micafungin15349122
    C. glabrata81Anidulafungin655182
Caspofungin856161
Micafungin165582
    C. tropicalis136Anidulafungin52667344
Caspofungin248582431
Micafungin738602353
    C. krusei9Anidulafungin45
Caspofungin72
Micafungin162
    C. guilliermondii7Anidulafungin1141
Caspofungin1231
Micafungin1132
    C. lusitaniae6Anidulafungin231
Caspofungin33
Micafungin141
    C. kefyr1Anidulafungin1
Caspofungin1
Micafungin1
    C. famata8Anidulafungin1124
Caspofungin11141
Micafungin2312
Latin America
    C. albicans533Anidulafungin341341851344222
Caspofungin7119249134195
Micafungin5736388232
    C. parapsilosis207Anidulafungin12106112310
Caspofungin252481771611
Micafungin11195010927
    C. glabrata63Anidulafungin842121
Caspofungin437184
Micafungin8532
    C. tropicalis222Anidulafungin53911947651
Caspofungin2611104252
Micafungin6799139421
    C. krusei18Anidulafungin981
Caspofungin675
Micafungin1152
    C. guilliermondii40Anidulafungin2320105
Caspofungin14101753
Micafungin4218151
    C. lusitaniae7Anidulafungin34
Caspofungin232
Micafungin52
    C. kefyr7Anidulafungin232
Caspofungin7
Micafungin43
    C. famata8Anidulafungin125
Caspofungin11141
Micafungin242
Europe
    C. albicans1,044Anidulafungin4726839926856114
Caspofungin122385342302541
Micafungin10874815525314
    C. parapsilosis190Anidulafungin434012419
Caspofungin15117179221
Micafungin172611145
    C. glabrata249Anidulafungin1141359171
Caspofungin1714669143
Micafungin281991831
    C. tropicalis153Anidulafungin7338719511
Caspofungin348742431
Micafungin860532831
    C. krusei87Anidulafungin3383691
Caspofungin132311841
Micafungin2126094
    C. guilliermondii9Anidulafungin1134
Caspofungin1332
Micafungin11142
    C. lusitaniae23Anidulafungin126131
Caspofungin271112
Micafungin1110101
    C. kefyr22Anidulafungin11011
Caspofungin2191
Micafungin616
    C. famata4Anidulafungin211
Caspofungin211
Micafungin112
North America
    C. albicans745Anidulafungin6424625412843514
Caspofungin18220354145431
Micafungin11450810214223
    C. parapsilosis209Anidulafungin273114722
Caspofungin512987222
Micafungin112910663
    C. glabrata354Anidulafungin2271761321421
Caspofungin2319612243411
Micafungin50274206121
    C. tropicalis114Anidulafungin333492162
Caspofungin129622011
Micafungin4453427211
    C. krusei22Anidulafungin19102
Caspofungin11632
Micafungin111721
    C. guilliermondii5Anidulafungin32
Caspofungin221
Micafungin221
    C. lusitaniae22Anidulafungin35131
Caspofungin21091
Micafungin21361
    C. kefyr7Anidulafungin142
Caspofungin34
Micafungin232
    C. famata4Anidulafungin112
Caspofungin121
Micafungin1111