TABLE 2.

In vitro susceptibilities of 5,346 clinical isolates of Candida spp. to anidulafungin, caspofungin, and micafungin

OrganismNo. of isolates testedAntifungal agentCumulative % of isolates susceptible at a MIC (μg/ml) ofa:
0.0070.0150.030.060.120.250.5124≥8
C. albicans 2,869Anidulafungin6.233.569.5 92.4 99.199.599.599.6100.0
Caspofungin1.726.774.2 97.1 99.399.9100.0
Micafungin11.980.6 96.4 99.399.499.599.6100.0
C. parapsilosis 759Anidulafungin0.30.30.31.44.727.9 92.5 100.0
Caspofungin0.10.53.310.752.289.5 98.6 99.9100.0
Micafungin0.10.30.30.56.124.479.3 100.0
C. glabrata 747Anidulafungin0.47.862.4 93.6 99.499.799.999.9100.0
Caspofungin7.065.2 95.3 98.499.299.799.999.999.9100.0
Micafungin13.7 91.4 97.998.999.599.999.9100.0
C. tropicalis 625Anidulafungin3.224.275.7 95.0 98.499.499.599.5100.0
Caspofungin1.331.079.7 97.3 99.099.799.799.899.899.8100.0
Micafungin4.039.577.6 96.3 98.699.599.7100.0
C. krusei 136Anidulafungin2.947.1 90.4 99.399.3100.0
Caspofungin0.70.741.975.7 94.9 99.3100.0
Micafungin2.213.285.3 96.3 100.0
C. guilliermondii 61Anidulafungin3.36.613.157.4 90.2 100.0
Caspofungin1.64.911.539.380.3 95.1 95.195.1100.0
Micafungin3.33.36.611.521.365.6 98.4 100.0
C. lusitaniae 58Anidulafungin1.713.843.1 96.6 100.0
Caspofungin3.46.944.889.7 96.6 100.0
Micafungin1.78.663.8 96.6 98.3100.0
C. kefyr 37Anidulafungin2.710.856.8 100.0
Caspofungin13.5 97.3 100.0
Micafungin5.440.5 100.0
C. famata 24Anidulafungin4.216.720.820.820.825.050.0 100.0
Caspofungin4.212.520.837.570.870.8 95.8 100.0
Micafungin4.216.716.720.833.375.0 91.7 100.0
Candida spp.30Anidulafungin3.330.050.063.363.373.386.7 93.3 96.796.7100.0
Caspofungin16.743.363.373.3 96.7 100.0
Micafungin20.053.366.766.786.7 100.0
Total5,346Anidulafungin3.721.148.972.682.083.484.788.7 98.8 99.9100.0
Caspofungin1.219.759.479.684.0 91.9 98.199.799.999.9100.0
Micafungin8.860.975.681.983.385.088.5 97.0 100.0
  • a Values corresponding to MICs at which at least 90% of isolates are inhibited are listed in bold type.