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antimicrobial susceptibility testing

  • Cefiderocol Antimicrobial Susceptibility Testing Considerations: the Achilles' Heel of the Trojan Horse?
    Minireview
    Cefiderocol Antimicrobial Susceptibility Testing Considerations: the Achilles' Heel of the Trojan Horse?

    Cefiderocol (formerly S-649266) is a novel siderophore-conjugated cephalosporin with activity against a broad array of multidrug-resistant (MDR), aerobic Gram-negative bacilli. The siderophore component binds iron and uses active iron transport for drug entry into the bacterial periplasmic space. The cephalosporin moiety is the active antimicrobial component, structurally resembling a hybrid between ceftazidime and cefepime. Like other...

    Patricia J. Simner, Robin Patel
  • Cefiderocol Antimicrobial Susceptibility Testing against Multidrug-Resistant Gram-Negative Bacilli: a Comparison of Disk Diffusion to Broth Microdilution
    Bacteriology
    Cefiderocol Antimicrobial Susceptibility Testing against Multidrug-Resistant Gram-Negative Bacilli: a Comparison of Disk Diffusion to Broth Microdilution

    Antimicrobial susceptibility testing (AST) of cefiderocol poses challenges because of its unique mechanism of action (i.e., requiring an iron-depleted state) and due to differences in interpretative criteria established by the Clinical and Laboratory Standards Institute (CLSI), U.S. Food and Drug Administration (FDA), and European Committee on Antimicrobial Susceptibility Testing (EUCAST). Our objective was to compare cefiderocol disk...

    C. Paul Morris, Yehudit Bergman, Tsigedera Tekle, John A. Fissel, Pranita D. Tamma, Patricia J. Simner
  • Variability in Zinc Concentration among Mueller-Hinton Broth Brands: Impact on Antimicrobial Susceptibility Testing of Metallo-β-Lactamase-Producing <em>Enterobacteriaceae</em>
    Bacteriology
    Variability in Zinc Concentration among Mueller-Hinton Broth Brands: Impact on Antimicrobial Susceptibility Testing of Metallo-β-Lactamase-Producing Enterobacteriaceae

    Zinc concentrations in cation-adjusted Mueller-Hinton broth (caMHB) from different manufacturers have been found to differ. Here, we evaluated the impact of utilizing different brands and lots of commercially available caMHB on the classification of the antimicrobial susceptibility of metallo-β-lactamase (MBL)-harboring Enterobacteriaceae. We also evaluated the addition of EDTA to caMHB as a means of achieving zinc-limited...

    Anastasia Bilinskaya, Douglas J. Buckheit, Michael Gnoinski, Tomefa E. Asempa, David P. Nicolau
  • A Novel Platform Using RNA Signatures To Accelerate Antimicrobial Susceptibility Testing in <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span>
    Bacteriology
    A Novel Platform Using RNA Signatures To Accelerate Antimicrobial Susceptibility Testing in Neisseria gonorrhoeae

    The rise of antimicrobial-resistant pathogens can be attributed to the lack of a rapid pathogen identification (ID) or antimicrobial susceptibility testing (AST), resulting in delayed therapeutic decisions at the point of care. Gonorrhea is usually empirically treated, with no AST results available before treatment, thus contributing to the rapid rise in drug resistance. Here, we present a rapid AST platform using RNA signatures for...

    Marjan M. Hashemi, Nikhil Ram-Mohan, Xi Yang, Nadya Andini, Nicholas R. Gessner, Karen C. Carroll, Tza-Huei Wang, Samuel Yang
  • Time to Result for Pathogen Identification and Antimicrobial Susceptibility Testing of Bronchoalveolar Lavage and Endotracheal Aspirate Specimens in U.S. Acute Care Hospitals
    Bacteriology
    Time to Result for Pathogen Identification and Antimicrobial Susceptibility Testing of Bronchoalveolar Lavage and Endotracheal Aspirate Specimens in U.S. Acute Care Hospitals

    Identification (ID) and antimicrobial susceptibility testing (AST) of respiratory pathogens are critical to the management of patients with pneumonia to facilitate optimal antibiotic therapy selection. Few studies have examined the time to results (TTR) for this critical specimen, and such data can be valuable for benchmarking the current paradigm of diagnostic approaches. TTR for bronchoalveolar lavage (BAL) and endotracheal aspirate (...

    Shawn H. MacVane, Niels Oppermann, Romney M. Humphries
  • Reporting Considerations for Cefepime-Susceptible and -Susceptible-Dose Dependent Results for Carbapenemase-Producing <em>Enterobacterales</em>
    Letter to the Editor
    Reporting Considerations for Cefepime-Susceptible and -Susceptible-Dose Dependent Results for Carbapenemase-Producing Enterobacterales
    J. A. Fissel, M. L. Yarbrough, T. Tekle, C.-A. D. Burnham, P. J. Simner
  • Open Access
    Species Identification and Antibiotic Resistance Prediction by Analysis of Whole-Genome Sequence Data by Use of ARESdb: an Analysis of Isolates from the Unyvero Lower Respiratory Tract Infection Trial
    Epidemiology
    Species Identification and Antibiotic Resistance Prediction by Analysis of Whole-Genome Sequence Data by Use of ARESdb: an Analysis of Isolates from the Unyvero Lower Respiratory Tract Infection Trial

    Whole-genome sequencing (WGS) is now routinely performed in clinical microbiology laboratories to assess isolate relatedness. With appropriately developed analytics, the same data can be used for prediction of antimicrobial susceptibility. We assessed WGS data for identification using open-source tools and antibiotic susceptibility testing (AST) prediction using ARESdb compared to matrix-assisted laser desorption ionization-time of...

    Ines Ferreira, Stephan Beisken, Lukas Lueftinger, Thomas Weinmaier, Matthias Klein, Johannes Bacher, Robin Patel, Arndt von Haeseler, Andreas E. Posch
  • Difficult-To-Detect <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>: <em>mecA</em>-Positive Isolates Associated with Oxacillin and Cefoxitin False-Susceptible Results
    Letter to the Editor
    Difficult-To-Detect Staphylococcus aureus: mecA-Positive Isolates Associated with Oxacillin and Cefoxitin False-Susceptible Results
    Amy S. Gargis, Brian B. Yoo, David R. Lonsway, Karen Anderson, Davina Campbell, Thomas O. Ewing, Adrian Lawsin, María-José Machado, Norihisa Yamamoto, Alison Laufer Halpin, Joseph D. Lutgring, Maria Karlsson, J. Kamile Rasheed, Christopher A. Elkins
  • Expanding U.S. Laboratory Capacity for <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Antimicrobial Susceptibility Testing and Whole-Genome Sequencing through the CDC's Antibiotic Resistance Laboratory Network
    Minireview
    Expanding U.S. Laboratory Capacity for Neisseria gonorrhoeae Antimicrobial Susceptibility Testing and Whole-Genome Sequencing through the CDC's Antibiotic Resistance Laboratory Network

    U.S. gonorrhea rates are rising, and antibiotic-resistant Neisseria gonorrhoeae (AR-Ng) is an urgent public health threat. Since implementation of nucleic acid amplification tests for N. gonorrhoeae identification, the capacity for culturing...

    Ellen N. Kersh, Cau D. Pham, John R. Papp, Robert Myers, Richard Steece, Grace Kubin, Romesh Gautom, Evelyn E. Nash, Samera Sharpe, Kim M. Gernert, Matthew Schmerer, Brian H. Raphael, Tara Henning, Anne M. Gaynor, Olusegun Soge, Karen Schlanger, Robert D. Kirkcaldy, Sancta B. St. Cyr, Elizabeth A. Torrone, Kyle Bernstein, Hillard Weinstock
    and the AR-Ng Working Group
  • <span class="named-content genus-species" id="named-content-1">Helicobacter pylori</span> Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing
    Bacteriology
    Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing

    The emergence of drug resistance in Helicobacter pylori has resulted in a greater need for susceptibility-guided treatment. While the alleles associated with resistance to clarithromycin and levofloxacin have been defined, there are limited data regarding the molecular mechanisms underlying resistance to other antimicrobials. Using...

    Rajagopalan Saranathan, Michael H. Levi, Alice R. Wattam, Adel Malek, Emmanuel Asare, Daniel S. Behin, Debra H. Pan, William R. Jacobs, Wendy A. Szymczak

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