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cervical intraepithelial neoplasia

  • Open Access
    Analytical and Clinical Sample Performance Characteristics of the Onclarity Assay for the Detection of Human Papillomavirus
    Virology
    Analytical and Clinical Sample Performance Characteristics of the Onclarity Assay for the Detection of Human Papillomavirus

    The objective of this study was to determine the result reproducibility and performance of the BD Onclarity human papillomavirus (HPV) assay (Onclarity) on the BD Viper LT platform using both contrived and clinical specimens. Reproducibility was assessed in BD SurePath liquid-based cytology (LBC) medium (SurePath) using contrived panels (HPV genotype 16 [HPV16] positive, HPV18 positive, or HPV45 positive) or clinical specimens (HPV16, -...

    Stephen Young, Laurence Vaughan, Karen Yanson, Karen Eckert, Aojun Li, James Harris, Aaron Ermel, James A. Williams, Mohammad Al-Ghoul, Catherine L. Cammarata, Stephanie N. Taylor, Ronald Luff, Charles K. Cooper, Barbara Van Der Pol
  • Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia
    Epidemiology
    Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia

    The objective was to assess the diagnostic test accuracy of high-risk human papillomavirus (hrHPV) testing of self-collected urine and cervicovaginal samples for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). We recruited a convenience sample of women 25 to 65 years of age who were undergoing clinically indicated colposcopy at two medical centers in North Carolina between November 2016 and January 2019....

    Eliane Rohner, Lisa Rahangdale, Busola Sanusi, Andrea K. Knittel, Laurence Vaughan, Kirsty Chesko, Brian Faherty, Samantha E. Tulenko, John W. Schmitt, LaHoma S. Romocki, Vijay Sivaraman, Julie A. E. Nelson, Jennifer S. Smith
  • Open Access
    Clinical Validation of the cobas HPV Test on the cobas 6800 System for the Purpose of Cervical Screening
    Virology
    Clinical Validation of the cobas HPV Test on the cobas 6800 System for the Purpose of Cervical Screening

    This study demonstrates that the clinical sensitivity, specificity, and reproducibility of the novel cobas human papillomavirus (HPV) test on the cobas 6800 system for high-risk HPV types fulfills the criteria for use in population-based cervical screening. The criteria were formulated by an international consortium, using the cobas 4800 HPV test as a validated reference assay.

    Marion Saville, Farhana Sultana, Michael J. Malloy, Louiza S. Velentzis, Michael Caruana, Ellen L. O. Ip, Marco H. T. Keung, Karen Canfell, Julia M. L. Brotherton, David Hawkes
  • Open Access
    Longitudinal Clinical Performance of the RNA-Based Aptima Human Papillomavirus (AHPV) Assay in Comparison to the DNA-Based Hybrid Capture 2 HPV Test in Two Consecutive Screening Rounds with a 6-Year Interval in Germany
    Virology
    Longitudinal Clinical Performance of the RNA-Based Aptima Human Papillomavirus (AHPV) Assay in Comparison to the DNA-Based Hybrid Capture 2 HPV Test in Two Consecutive Screening Rounds with a 6-Year Interval in Germany

    Longitudinal data on the E6/E7 mRNA-based Aptima human papillomavirus (AHPV) assay exceeding three years in comparison to the gold standard Digene Hybrid Capture 2 (HC2) test are not available. We previously reported the cross-sectional data of the German AHPV Screening Trial (GAST) in which 10,040 women were recruited and tested by liquid-based cytology, the HC2 assay, and the AHPV assay.

    Thomas Iftner, Klaus-Joachim Neis, Alejandra Castanon, Rebecca Landy, Barbara Holz, Astrid Woll-Herrmann, Angelika Iftner, Annette Staebler, Diethelm Wallwiener, Claus Hann von Weyhern, Felix Neis, Juliane Haedicke-Jarboui, Peter Martus, Sara Brucker, Melanie Henes, Peter Sasieni
  • Virology
    Human Papillomavirus DNA Detection in Menstrual Blood from Patients with Cervical Intraepithelial Neoplasia and Condyloma Acuminatum
    Sze Chuen Cesar Wong, Thomas Chi Chuen Au, Sammy Chung Sum Chan, Charles Ming Lok Chan, Money Yan Yee Lam, Benny Chung Ying Zee, Wei Mei Pong, Anthony Tak Cheung Chan
  • Virology
    Clinical Performance of Human Papillomavirus E6 and E7 mRNA Testing for High-Grade Lesions of the Cervix
    Paola Cattani, Gian Franco Zannoni, Caterina Ricci, Sara D'Onghia, Ilaria Nausica Trivellizzi, Aldo Di Franco, Valerio G. Vellone, Maria Durante, Giovanni Fadda, Giovanni Scambia, Giovanni Capelli, Rosa De Vincenzo
  • Virology
    Comparison of GP5+/6+-PCR and SPF10-Line Blot Assays for Detection of High-Risk Human Papillomavirus in Samples from Women with Normal Cytology Results Who Develop Grade 3 Cervical Intraepithelial Neoplasia
    A. T. Hesselink, M. A. P. C. van Ham, D. A. M. Heideman, Z. M. A. Groothuismink, L. Rozendaal, J. Berkhof, F. J. van Kemenade, L. A. F. G. Massuger, W. J. G. Melchers, C. J. L. M. Meijer, P. J. F. Snijders
  • Virology
    Genotyping of Human Papillomaviruses by a Novel One-Step Typing Method with Multiplex PCR and Clinical Applications
    Morie Nishiwaki, Tomohiro Yamamoto, Somako Tone, Taichi Murai, Tatsuya Ohkawara, Takakuni Matsunami, Motoiki Koizumi, Yoshitake Takagi, Jun Yamaguchi, Nobuo Kondo, Jun Nishihira, Takeharu Horikawa, Takashi Yoshiki
  • Virology
    Human Papillomavirus (HPV) in Atypical Squamous Cervical Cytology: the Invader HPV Test as a New Screening Assay
    Anna K. Wong, Raymond C.-K. Chan, W. Stephen Nichols, Shikha Bose
  • Virology
    Evaluation of a Commercialized In Situ Hybridization Assay for Detecting Human Papillomavirus DNA in Tissue Specimens from Patients with Cervical Intraepithelial Neoplasia and Cervical Carcinoma
    Ming Guo, Yun Gong, Michael Deavers, Elvio G. Silva, Yee Jee Jan, David E. Cogdell, Rajyalashmi Luthra, E. Lin, Hung Cheng Lai, Wei Zhang, Nour Sneige

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