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Clostridium difficile

  • Evaluation of a Combined Multilocus Sequence Typing and Whole-Genome Sequencing Two-Step Algorithm for Routine Typing of <em>Clostridioides difficile</em>
    Bacteriology
    Evaluation of a Combined Multilocus Sequence Typing and Whole-Genome Sequencing Two-Step Algorithm for Routine Typing of Clostridioides difficile

    Multilocus sequence typing (MLST) is a low-resolution but rapid genotyping method for Clostridioides difficile. Whole-genome sequencing (WGS) has emerged as the new gold standard for C. difficile typing, but cost and lack of standardization still limit broad utilization. In this study, we evaluated...

    Mini Kamboj, Tracy McMillen, Mustafa Syed, Hoi Yan Chow, Krupa Jani, Anoshe Aslam, Jennifer Brite, Brian Fanelli, Nur A. Hasan, Manoj Dadlani, Lars Westblade, Ahmet Zehir, Matthew Simon, N. Esther Babady
  • Laboratory-Based Surveillance of <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Infection in Australian Health Care and Community Settings, 2013 to 2018
    Bacteriology
    Laboratory-Based Surveillance of Clostridium difficile Infection in Australian Health Care and Community Settings, 2013 to 2018

    In the early 2000s, a binary toxin (CDT)-producing strain of Clostridium difficile, ribotype 027 (RT027), caused extensive outbreaks of diarrheal disease in North America and Europe. This strain has not become established in Australia, and there is a markedly different repertoire of circulating strains there compared to other regions of the world. The...

    Stacey Hong, Papanin Putsathit, Narelle George, Christine Hemphill, Peter G. Huntington, Tony M. Korman, Despina Kotsanas, Monica Lahra, Rodney McDougall, Casey V. Moore, Graeme R. Nimmo, Louise Prendergast, Jennifer Robson, Lynette Waring, Michael C. Wehrhahn, Gerhard F. Weldhagen, Richard M. Wilson, Thomas V. Riley, Daniel R. Knight
  • Ultrasensitive <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Toxin Testing for Higher Diagnostic Accuracy
    Minireview
    Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy

    Currently available diagnostic tests for Clostridioides difficile infection (CDI) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing algorithms. Ultrasensitive assays for detection of C. difficile toxins provide measurements of disease-specific markers...

    Johanna Sandlund, Kerrie Davies, Mark H. Wilcox
  • Prospective Evaluation of the mariPOC Test for Detection of <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Glutamate Dehydrogenase and Toxins A/B
    Immunoassays
    Prospective Evaluation of the mariPOC Test for Detection of Clostridioides difficile Glutamate Dehydrogenase and Toxins A/B

    The objective of this study was to evaluate a novel automated random-access test, mariPOC CDI (ArcDia Ltd., Finland), for the detection of Clostridioides difficile glutamate dehydrogenase (GDH) and toxins A and B directly from fecal specimens. The mariPOC test was compared with both the GenomEra C....

    Roosa Savolainen, Juha M. Koskinen, Silja Mentula, Janne O. Koskinen, Suvi-Sirkku Kaukoranta
  • Open Access
    A Multicenter Study of the Revogene <span class="named-content genus-species" id="named-content-1">C. difficile</span> System for Detection of the Toxin B Gene from Unformed Stool Specimens
    Bacteriology
    A Multicenter Study of the Revogene C. difficile System for Detection of the Toxin B Gene from Unformed Stool Specimens

    Clostridioides difficile is the leading cause of diarrhea in hospitalized U.S. patients and results in over 400,000 cases of C. difficile infection per year. C. difficile infections have mortality rates of 6 to 30% and...

    Michael J. Mashock, Matthew L. Faron, Karen C. Carroll, Christina Dang, Shawna Lewis, Hossein Salimnia, Paul Lephart, Vivian G. Loo, Bryan H. Schmitt, Stephen Young, Blake W. Buchan, Nathan A. Ledeboer
  • Open Access
    Hash-Based Core Genome Multilocus Sequence Typing for <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span>
    Bacteriology
    Hash-Based Core Genome Multilocus Sequence Typing for Clostridium difficile

    Pathogen whole-genome sequencing has huge potential as a tool to better understand infection transmission. However, rapidly identifying closely related genomes among a background of thousands of other genomes is challenging. Here, we describe a refinement to core genome multilocus sequence typing (cgMLST) in which alleles at each gene are reproducibly converted to a unique hash, or short string of letters (hash-cgMLST).

    ...
    David W. Eyre, Tim E. A. Peto, Derrick W. Crook, A. Sarah Walker, Mark H. Wilcox
  • Open Access
    Performance Evaluation of the Luminex Aries <span class="named-content genus-species" id="named-content-1">C. difficile</span> Assay in Comparison to Two Other Molecular Assays within a Multihospital Health Care Center
    Bacteriology
    Performance Evaluation of the Luminex Aries C. difficile Assay in Comparison to Two Other Molecular Assays within a Multihospital Health Care Center

    Clostridioides difficile infection (CDI) remain a serious issue in the United States. Fast and accurate diagnosis of CDI is paramount to achieve immediate infection control initiation, triaging, and isolation, as well as appropriate antibiotic treatment. However, both, over- and underdiagnosis can lead to adverse patient outcomes, such as unnecessary administration of...

    Stefan Juretschko, Ryhana Manji, Reeti Khare, Shubhagata Das, Sherry Dunbar
  • Evaluation of a Gastrointestinal Pathogen Panel Immunoassay in Stool Testing of Patients with Suspected <em>Clostridioides</em> (<em>Clostridium</em>) <em>difficile</em> Infection
    Immunoassays
    Evaluation of a Gastrointestinal Pathogen Panel Immunoassay in Stool Testing of Patients with Suspected Clostridioides (Clostridium) difficile Infection

    Clostridioides (Clostridium) difficile infection (CDI) is the most common causative pathogen of health care-associated gastrointestinal infections; however, due to the overlap of clinical symptoms with those of other causes of acute gastroenteritis, the selection of the most appropriate laboratory test is difficult.

    Marcela Krutova, Ales Briksi, Jan Tkadlec, Miroslav Zajac, Jana Matejkova, Otakar Nyc, Pavel Drevinek
  • Guidelines Support the Value of Stand-Alone Nucleic Acid Amplification Tests for <em>Clostridioides</em> (<em>Clostridium</em>) <em>difficile</em> Infection
    Letter to the Editor
    Guidelines Support the Value of Stand-Alone Nucleic Acid Amplification Tests for Clostridioides (Clostridium) difficile Infection
    Fred C. Tenover, David H. Persing, Ferric Fang
  • <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Whole-Genome Sequencing Reveals Limited Within-Host Genetic Diversity in a Pediatric Cohort
    Epidemiology
    Clostridioides difficile Whole-Genome Sequencing Reveals Limited Within-Host Genetic Diversity in a Pediatric Cohort

    Whole-genome sequencing (WGS) is a highly sensitive method for identifying genetic relatedness and transmission of Clostridioides difficile strains. Previous studies suggest that as few as 3 core genome single-nucleotide variants (SNVs) discriminate between genetically distinct isolates. Because a single C...

    Aakash Balaji, Egon A. Ozer, Larry K. Kociolek

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