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Journal of Clinical Microbiology
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CLSI

  • Evaluation of Surrogate Tests for the Presence of <em>mecA</em>-Mediated Methicillin Resistance in <span class="named-content genus-species" id="named-content-1">Staphylococcus capitis</span>, <span class="named-content genus-species" id="named-content-2">Staphylococcus haemolyticus</span>, <span class="named-content genus-species" id="named-content-3">Staphylococcus hominis</span>, and <span class="named-content genus-species" id="named-content-4">Staphylococcus warneri</span>
    Bacteriology
    Evaluation of Surrogate Tests for the Presence of mecA-Mediated Methicillin Resistance in Staphylococcus capitis, Staphylococcus haemolyticus, Staphylococcus hominis, and Staphylococcus warneri

    Testing of staphylococci other than Staphylococcus aureus (SOSA) for mecA-mediated resistance is challenging. Isolates of Staphylococcus capitis, Staphylococcus haemolyticus,...

    Romney M. Humphries, Paul Magnano, Carey-Ann D. Burnham, Jennifer Dien Bard, Tanis C. Dingle, Katrina Callan, Lars F. Westblade
    and the Coagulase Negative Staphylococcus Ad Hoc Working Group
  • One Size Fits All? Application of Susceptible-Dose-Dependent Breakpoints to Pediatric Patients and Laboratory Reporting
    Commentary
    One Size Fits All? Application of Susceptible-Dose-Dependent Breakpoints to Pediatric Patients and Laboratory Reporting

    The Clinical and Laboratory Standards Institute antimicrobial and antifungal standards define a susceptible-dose-dependent (SDD) category for certain organisms and drug combinations. Reporting MICs within the SDD category suggests that treatment success is likely with increased drug exposure. These breakpoints are based on pharmacokinetic, pharmacodynamic, and clinical outcome data from adults and not pediatric patients.

    ...
    Lindsey E. Nielsen, Jeanne B. Forrester, Jennifer Ellis Girotto, Aimee M. Dassner, Romney Humphries
  • Susceptibility Categories Should Be Agreed Upon
    Letter to the Editor
    Susceptibility Categories Should Be Agreed Upon
    Ernst Molitor
  • The New, New Daptomycin Breakpoint for <em>Enterococcus</em> spp.
    Commentary
    The New, New Daptomycin Breakpoint for Enterococcus spp.

    In 2019, the Clinical and Laboratory Standards Institute revised the daptomycin breakpoints for Enterococcus spp. twice in rapid succession.

    Romney M. Humphries
  • Don't Get Wound Up: Revised Fluoroquinolone Breakpoints for <span class="named-content genus-species" id="named-content-1">Enterobacteriaceae</span> and <span class="named-content genus-species" id="named-content-2">Pseudomonas aeruginosa</span>
    Minireview
    Don't Get Wound Up: Revised Fluoroquinolone Breakpoints for Enterobacteriaceae and Pseudomonas aeruginosa

    Fluoroquinolones remain some of the more commonly prescribed antimicrobial agents in the United States, despite the wide array of reported side effects that are associated with their use. In 2019, the Clinical and Laboratory Standards Institute revised the fluoroquinolone antimicrobial susceptibility testing breakpoints for both Enterobacteriaceae and...

    Tam T. Van, Emi Minejima, Chiao An Chiu, Susan M. Butler-Wu
  • Understanding and Addressing CLSI Breakpoint Revisions: a Primer for Clinical Laboratories
    Minireview
    Understanding and Addressing CLSI Breakpoint Revisions: a Primer for Clinical Laboratories

    The Clinical and Laboratory Standards Institute (CLSI) has revised several breakpoints since 2010 for bacteria that grow aerobically. In 2019, these revisions include changes to the ciprofloxacin and levofloxacin breakpoints for the Enterobacteriaceae and Pseudomonas aeruginosa, daptomycin...

    Romney M. Humphries, April N. Abbott, Janet A. Hindler
  • Minireview
    The Continued Value of Disk Diffusion for Assessing Antimicrobial Susceptibility in Clinical Laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group

    Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.

    Romney M. Humphries, Susan Kircher, Andrea Ferrell, Kevin M. Krause, Rianna Malherbe, Andre Hsiung, Carey-Ann D. Burnham
  • Minireview
    CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests
    Romney M. Humphries, Jane Ambler, Stephanie L. Mitchell, Mariana Castanheira, Tanis Dingle, Janet A. Hindler, Laura Koeth, Katherine Sei
    and on behalf of the CLSI Methods Development and Standardization Working Group of the Subcommittee on Antimicrobial Susceptibility Testing
  • Bacteriology
    An Improved Extended-Spectrum-β-Lactamase Detection Test Utilizing Aztreonam plus Clavulanate
    Gina K. Thomson, Maaz Ayaz, Kelli Lutes, Kenneth S. Thomson
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