core genome MLST

  • Open Access
    Hash-Based Core Genome Multilocus Sequence Typing for <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span>
    Bacteriology
    Hash-Based Core Genome Multilocus Sequence Typing for Clostridium difficile

    Pathogen whole-genome sequencing has huge potential as a tool to better understand infection transmission. However, rapidly identifying closely related genomes among a background of thousands of other genomes is challenging. Here, we describe a refinement to core genome multilocus sequence typing (cgMLST) in which alleles at each gene are reproducibly converted to a unique hash, or short string of letters (hash-cgMLST).

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    David W. Eyre, Tim E. A. Peto, Derrick W. Crook, A. Sarah Walker, Mark H. Wilcox
  • Open Access
    A Core Genome Multilocus Sequence Typing Scheme for <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span>
    Bacteriology
    A Core Genome Multilocus Sequence Typing Scheme for Enterococcus faecalis

    Among enterococci, Enterococcus faecalis occurs ubiquitously, with the highest incidence of human and animal infections. The high genetic plasticity of E. faecalis complicates both molecular investigations and phylogenetic analyses.

    Bernd Neumann, Karola Prior, Jennifer K. Bender, Dag Harmsen, Ingo Klare, Stephan Fuchs, Astrid Bethe, Daniela Zühlke, André Göhler, Stefan Schwarz, Kirsten Schaffer, Katharina Riedel, Lothar H. Wieler, Guido Werner
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