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COVID-19

  • Free
    Analytical Sensitivity of the Abbott BinaxNOW COVID-19 Ag Card
    Virology
    Analytical Sensitivity of the Abbott BinaxNOW COVID-19 Ag Card

    Multiple rapid antigen (Ag) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have recently received emergency-use authorization (EUA) from the U.S. Food and Drug Administration (FDA).

    Garrett A. Perchetti, Meei-Li Huang, Margaret G. Mills, Keith R. Jerome, Alexander L. Greninger
  • Free
    Frequency of Positive <em>Aspergillus</em> Tests in COVID-19 Patients in Comparison to Other Patients with Pulmonary Infections Admitted to the Intensive Care Unit
    Mycology
    Frequency of Positive Aspergillus Tests in COVID-19 Patients in Comparison to Other Patients with Pulmonary Infections Admitted to the Intensive Care Unit

    The aim of this study was to describe the frequency of positive Aspergillus tests in COVID-19 patients and investigate the association between COVID-19 and a positive Aspergillus test result. We compared the proportion of positive Aspergillus tests in COVID-19 patients admitted to the intensive care unit (ICU) for >24 h with two control groups: patients with community-acquired pneumonia with (i) a PCR-...

    Erlangga Yusuf, Alieke Vonk, Johannes P. C. van den Akker, Lonneke Bode, Gregorius J. Sips, Bart J. A. Rijnders, Jurriaan de Steenwinkel, Nelianne J. Verkaik, Marius Vogel, Menno van der Eerden, Mireille van Westreenen
  • Free
    Multicenter Evaluation of the Clinical Performance and the Neutralizing Antibody Activity Prediction Properties of 10 High-Throughput Serological Assays Used in Clinical Laboratories
    Immunoassays
    Multicenter Evaluation of the Clinical Performance and the Neutralizing Antibody Activity Prediction Properties of 10 High-Throughput Serological Assays Used in Clinical Laboratories

    As the coronavirus disease 2019 (COVID-19) pandemic second wave is emerging, it is of the upmost importance to screen the population immunity in order to keep track of infected individuals. Consequently, immunoassays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high specificity and positive predictive values are needed to obtain an accurate epidemiological picture.

    C. Therrien, B. Serhir, M. Bélanger-Collard, J. Skrzypczak, D. K. Shank, C. Renaud, J. Girouard, V. Loungnarath, M. Carrier, G. Brochu, F. Tourangeau, B. Gilfix, A. Piche, R. Bazin, R. Guérin, M. Lavoie, V. Martel-Laferrière, C. Fortin, A. Benoit, D. Marcoux, N. Gauthier, A. M. Laumaea, R. Gasser, A. Finzi, M. Roger
  • Open Access
    Variable Sensitivity of SARS-CoV-2 Molecular Detection in European Expert Laboratories: External Quality Assessment, June and July 2020
    Virology
    Variable Sensitivity of SARS-CoV-2 Molecular Detection in European Expert Laboratories: External Quality Assessment, June and July 2020

    During the ongoing coronavirus disease 2019 (COVID-19) outbreak, robust detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key element for clinical management and to interrupt transmission chains. We organized an external quality assessment (EQA) of molecular detection of SARS-CoV-2 for European expert laboratories. An EQA panel composed of 12 samples, containing either SARS-CoV-2 at different concentrations...

    Carlo Fischer, Ramona Mögling, Angeliki Melidou, Arne Kühne, Edmilson F. Oliveira-Filho, Thorsten Wolff, Janine Reiche, Eeva Broberg, Christian Drosten, Adam Meijer, Katrin Leitmeyer, Jan Felix Drexler, Chantal B. E. M. Reusken
  • Free
    Saliva Is a Promising Alternative Specimen for the Detection of SARS-CoV-2 in Children and Adults
    Virology
    Saliva Is a Promising Alternative Specimen for the Detection of SARS-CoV-2 in Children and Adults

    Testing efforts for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been burdened by the scarcity of testing materials and personal protective equipment for health care workers. The simple and painless process of saliva collection allows for widespread testing, but enthusiasm is hampered by variable performance compared to that of nasopharyngeal swab (NPS) samples.

    Rebecca Yee, Thao T. Truong, Pia S. Pannaraj, Natalie Eubanks, Emily Gai, Jaycee Jumarang, Lauren Turner, Ariana Peralta, Yesun Lee, Jennifer Dien Bard
  • Free
    A Multiplex Microsphere IgG Assay for SARS-CoV-2 Using ACE2-Mediated Inhibition as a Surrogate for Neutralization
    Immunoassays
    A Multiplex Microsphere IgG Assay for SARS-CoV-2 Using ACE2-Mediated Inhibition as a Surrogate for Neutralization

    The coronavirus disease 2019 (COVID-19) pandemic has highlighted the challenges inherent to the serological detection of a novel pathogen such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Serological tests can be used diagnostically and for surveillance, but their usefulness depends on their throughput, sensitivity, and specificity. Here, we describe a multiplex fluorescent microsphere-based assay, 3Flex, that can...

    Andrew Cameron, Claire A. Porterfield, Larry D. Byron, Jiong Wang, Zachary Pearson, Jessica L. Bohrhunter, Anthony B. Cardillo, Lindsay Ryan-Muntz, Ryan A. Sorensen, Mary T. Caserta, Stephen Angeloni, Dwight J. Hardy, Martin S. Zand, Nicole D. Pecora
  • Free
    Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera
    Immunoassays
    Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera

    Surrogate neutralization assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be done without biosafety level 3 containment and in multiple species are desirable. We evaluate a recently developed surrogate virus neutralization test (sVNT) in comparison to 90% plaque reduction neutralization tests (PRNT90) in human, canine, cat, and hamster sera. With PRNT90 as the reference, sVNT had...

    Ranawaka A. P. M. Perera, Ronald Ko, Owen T. Y. Tsang, David S. C. Hui, Mike Y. M. Kwan, Christopher J. Brackman, Esther M. W. To, Hui-ling Yen, Kathy Leung, Samuel M. S. Cheng, Kin Ho Chan, Karl C. K. Chan, Ka-Chi Li, Linda Saif, Vanessa R. Barrs, Joseph T. Wu, Thomas H. C. Sit, Leo L. M. Poon, Malik Peiris
  • Free
    Inference of Active Viral Replication in Cases with Sustained Positive Reverse Transcription-PCR Results for SARS-CoV-2
    Virology
    Inference of Active Viral Replication in Cases with Sustained Positive Reverse Transcription-PCR Results for SARS-CoV-2

    The purpose of this study was to detect coronavirus disease 2019 (COVID-19) cases with persistent positive reverse transcription-PCR (RT-PCR) results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which viable virus can be inferred due to the presence of subgenomic (SG) viral RNA, which is expressed only in replicating viruses. RNA remnants purified from diagnostic nasopharyngeal specimens were used as the...

    Cristina Rodríguez-Grande, Javier Adán-Jiménez, Pilar Catalán, Luis Alcalá, Agustín Estévez, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma
    and on behalf of the Gregorio Marañón Microbiology-ID COVID-19 Study Group
  • Free
    Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers
    Virology
    Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers

    Accurate serological assays to detect antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to characterize the epidemiology of SARS-CoV-2 infection and identify potential candidates for coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) donation. This study compared the performances of commercial enzyme immunoassays (EIAs) with respect to detection of IgG or total antibodies to SARS-CoV-2 and...

    Eshan U. Patel, Evan M. Bloch, William Clarke, Yu-Hsiang Hsieh, Denali Boon, Yolanda Eby, Reinaldo E. Fernandez, Owen R. Baker, Morgan Keruly, Charles S. Kirby, Ethan Klock, Kirsten Littlefield, Jernelle Miller, Haley A. Schmidt, Philip Sullivan, Estelle Piwowar-Manning, Ruchee Shrestha, Andrew D. Redd, Richard E. Rothman, David Sullivan, Shmuel Shoham, Arturo Casadevall, Thomas C. Quinn, Andrew Pekosz, Aaron A. R. Tobian, Oliver Laeyendecker
  • Free
    Comparison of the Quidel Sofia SARS FIA Test to the Hologic Aptima SARS-CoV-2 TMA Test for Diagnosis of COVID-19 in Symptomatic Outpatients
    Virology
    Comparison of the Quidel Sofia SARS FIA Test to the Hologic Aptima SARS-CoV-2 TMA Test for Diagnosis of COVID-19 in Symptomatic Outpatients

    The Quidel Sofia severe acute respiratory syndrome (SARS) fluorescent immunoassay (FIA) test (SOFIA) is a rapid antigen immunoassay for the detection of SARS coronavirus 2 (SARS-CoV-2) proteins from nasal or nasopharyngeal swab specimens. The purpose of this study was to compare the results of the SOFIA test to those of the Hologic Aptima SARS-CoV-2 TMA test (APTIMA TMA), a high-throughput molecular diagnostic test that uses...

    Eric T. Beck, Wendy Paar, Lara Fojut, Jordan Serwe, Renee R. Jahnke

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