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CSF

  • Comparative Analysis of the Euroimmun CXCL13 Enzyme-Linked Immunosorbent Assay and the ReaScan Lateral Flow Immunoassay for Diagnosis of Lyme Neuroborreliosis
    Bacteriology
    Comparative Analysis of the Euroimmun CXCL13 Enzyme-Linked Immunosorbent Assay and the ReaScan Lateral Flow Immunoassay for Diagnosis of Lyme Neuroborreliosis

    Diagnosis of Lyme neuroborreliosis (LNB) is challenging, as long as Borrelia-specific intrathecal antibodies are not yet detectable. The chemokine CXCL13 is elevated in the cerebrospinal fluid (CSF) of LNB patients. Here, we compared the performances of the Euroimmun CXCL13 enzyme-linked immunosorbent assay (CXCL13 ELISA) and the ReaScan CXCL13 lateral flow immunoassay (CXCL13 LFA), a rapid point-of-care test, to support the...

    Katharina Ziegler, Anca Rath, Christoph Schoerner, Renate Meyer, Thomas Bertsch, Frank Erbguth, Christian Bogdan, Jörg Steinmann, Jürgen Held
  • Bacteriology
    Development and Optimization of Metagenomic Next-Generation Sequencing Methods for Cerebrospinal Fluid Diagnostics
    Patricia J. Simner, Heather B. Miller, Florian P. Breitwieser, Gabriel Pinilla Monsalve, Carlos A. Pardo, Steven L. Salzberg, Cynthia L. Sears, David L. Thomas, Charles G. Eberhart, Karen C. Carroll
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