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levofloxacin

  • <span class="named-content genus-species" id="named-content-1">Helicobacter pylori</span> Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing
    Bacteriology
    Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing

    The emergence of drug resistance in Helicobacter pylori has resulted in a greater need for susceptibility-guided treatment. While the alleles associated with resistance to clarithromycin and levofloxacin have been defined, there are limited data regarding the molecular mechanisms underlying resistance to other antimicrobials. Using...

    Rajagopalan Saranathan, Michael H. Levi, Alice R. Wattam, Adel Malek, Emmanuel Asare, Daniel S. Behin, Debra H. Pan, William R. Jacobs, Wendy A. Szymczak
  • Activity of Potential Alternative Treatment Agents for <span class="named-content genus-species" id="named-content-1">Stenotrophomonas maltophilia</span> Isolates Nonsusceptible to Levofloxacin and/or Trimethoprim-Sulfamethoxazole
    Bacteriology
    Activity of Potential Alternative Treatment Agents for Stenotrophomonas maltophilia Isolates Nonsusceptible to Levofloxacin and/or Trimethoprim-Sulfamethoxazole

    Stenotrophomonas maltophilia is difficult to treat due to the production of multiple intrinsic and acquired mechanisms of resistance. Trimethoprim-sulfamethoxazole (TMP-SMZ) and the fluoroquinolones have traditionally been considered the drugs of choice but are plagued by increasing resistance and adverse drug effects. The objective of this study was to evaluate the...

    M. Biagi, X. Tan, T. Wu, M. Jurkovic, A. Vialichka, K. Meyer, R. E. Mendes, E. Wenzler
  • Effect of Clinically Meaningful Antibiotic Concentrations on Recovery of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> and <span class="named-content genus-species" id="named-content-2">Klebsiella pneumoniae</span> Isolates from Anaerobic Blood Culture Bottles with and without Antibiotic Binding Resins
    Bacteriology
    Effect of Clinically Meaningful Antibiotic Concentrations on Recovery of Escherichia coli and Klebsiella pneumoniae Isolates from Anaerobic Blood Culture Bottles with and without Antibiotic Binding Resins

    Blood cultures are routinely collected in pairs of aerobic and anaerobic bottles. Artificial sterilization of Gram-negative bacteria in aerobic bottles containing clinically meaningful antibiotic concentrations has previously been observed. This study assessed recovery from anaerobic bottles with and without antibiotic binding resins.

    Iris H. Chen, David P. Nicolau, Joseph L. Kuti
  • Recovery of Gram-Negative Bacteria from Aerobic Blood Culture Bottles Containing Antibiotic Binding Resins after Exposure to β-Lactam and Fluoroquinolone Concentrations
    Bacteriology
    Recovery of Gram-Negative Bacteria from Aerobic Blood Culture Bottles Containing Antibiotic Binding Resins after Exposure to β-Lactam and Fluoroquinolone Concentrations

    Blood culture bottles containing antibiotic binding resins are routinely used to minimize artificial sterilization in the presence of antibiotics. However, the resin binding kinetics can differ between antibiotics and concentrations.

    Iris H. Chen, David P. Nicolau, Joseph L. Kuti
  • Don't Get Wound Up: Revised Fluoroquinolone Breakpoints for <span class="named-content genus-species" id="named-content-1">Enterobacteriaceae</span> and <span class="named-content genus-species" id="named-content-2">Pseudomonas aeruginosa</span>
    Minireview
    Don't Get Wound Up: Revised Fluoroquinolone Breakpoints for Enterobacteriaceae and Pseudomonas aeruginosa

    Fluoroquinolones remain some of the more commonly prescribed antimicrobial agents in the United States, despite the wide array of reported side effects that are associated with their use. In 2019, the Clinical and Laboratory Standards Institute revised the fluoroquinolone antimicrobial susceptibility testing breakpoints for both Enterobacteriaceae and...

    Tam T. Van, Emi Minejima, Chiao An Chiu, Susan M. Butler-Wu
  • Evaluation of Ciprofloxacin and Levofloxacin Disk Diffusion and Etest Using the 2019 <em>Enterobacteriaceae</em> CLSI Breakpoints
    Bacteriology
    Evaluation of Ciprofloxacin and Levofloxacin Disk Diffusion and Etest Using the 2019 Enterobacteriaceae CLSI Breakpoints

    In 2019, the Clinical and Laboratory Standards Institute (CLSI) published revisions to the Enterobacteriaceae ciprofloxacin and levofloxacin breakpoints. We evaluated the performance of disk diffusion and Etest compared to that of reference broth microdilution by use of the revised breakpoints.

    Romney M. Humphries, Janet A. Hindler, Keith Shaffer, Shelley A. Campeau
  • CASE REPORTS
    First Report of Treatment of Anaerobiospirillum succiniciproducens Bloodstream Infection with Levofloxacin
    Theodoros Kelesidis, Jennifer Dien Bard, Romney Humphries, Kevin Ward, Michael A. Lewinski, Daniel Z. Uslan
  • Bacteriology
    Evaluation of a New Test, GenoType HelicoDR, for Molecular Detection of Antibiotic Resistance in Helicobacter pylori
    Emmanuelle Cambau, Vera Allerheiligen, Céline Coulon, Céline Corbel, Christine Lascols, Lionel Deforges, Claude-James Soussy, Jean-Charles Delchier, Francis Megraud
  • Bacteriology
    Molecular Characterization of Emerging Non-Levofloxacin-Susceptible Pneumococci Isolated from Children in South Africa
    Nicole Wolter, Mignon du Plessis, Anne von Gottberg, Linda de Gouveia, Keith P. Klugman
  • CASE REPORTS
    Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation
    M. de Cueto, J. M. Rodríguez, M. J. Soriano, L. López-Cerero, J. Venero, A. Pascual

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