limit of detection

  • Open Access
    How Well Do Routine Molecular Diagnostics Detect Rifampin Heteroresistance in <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>?
    Mycobacteriology and Aerobic Actinomycetes
    How Well Do Routine Molecular Diagnostics Detect Rifampin Heteroresistance in Mycobacterium tuberculosis?

    Rifampin heteroresistance—where rifampin-resistant and -susceptible tuberculosis (TB) bacilli coexist—may result in failed standard TB treatment and potential spread of rifampin-resistant strains. The detection of rifampin heteroresistance in routine rapid diagnostic tests (RDTs) allows for patients to receive prompt and effective multidrug-resistant-TB treatment and may improve rifampin-resistant TB control.

    Kamela C. S. Ng, Philip Supply, Frank G. J. Cobelens, Cyril Gaudin, Julian Gonzalez-Martin, Bouke C. de Jong, Leen Rigouts
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