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Neisseria meningitidis

  • Open Access
    Meningococcal Deduced Vaccine Antigen Reactivity (MenDeVAR) Index: a Rapid and Accessible Tool That Exploits Genomic Data in Public Health and Clinical Microbiology Applications
    Bacteriology
    Meningococcal Deduced Vaccine Antigen Reactivity (MenDeVAR) Index: a Rapid and Accessible Tool That Exploits Genomic Data in Public Health and Clinical Microbiology Applications

    As microbial genomics makes increasingly important contributions to clinical and public health microbiology, the interpretation of whole-genome sequence data by nonspecialists becomes essential. In the absence of capsule-based vaccines, two protein-based vaccines have been used for the prevention of invasive serogroup B meningococcal disease (IMD) since their licensure in 2013 and 2014. These vaccines have different components and...

    Charlene M. C. Rodrigues, Keith A. Jolley, Andrew Smith, J. Claire Cameron, Ian M. Feavers, Martin C. J. Maiden
  • Open Access
    Full Molecular Typing of <span class="named-content genus-species" id="named-content-1">Neisseria meningitidis</span> Directly from Clinical Specimens for Outbreak Investigation
    Epidemiology
    Full Molecular Typing of Neisseria meningitidis Directly from Clinical Specimens for Outbreak Investigation

    Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis worldwide and an occasional cause of meningococcal urethritis. When isolates are unavailable for surveillance or outbreak investigations, molecular characterization of pathogens needs to be performed directly from clinical specimens, such as cerebrospinal fluid (CSF), blood, or urine. However...

    Mark Itsko, Adam C. Retchless, Sandeep J. Joseph, Abigail Norris Turner, Jose A. Bazan, Adodo Yao Sadji, Rasmata Ouédraogo-Traoré, Xin Wang
  • Validation of a New Rapid Detection Test for Detection of <span class="named-content genus-species" id="named-content-1">Neisseria meningitidis</span> A/C/W/X/Y Antigens in Cerebrospinal Fluid
    Bacteriology
    Validation of a New Rapid Detection Test for Detection of Neisseria meningitidis A/C/W/X/Y Antigens in Cerebrospinal Fluid

    Meningococcal meningitis remains a life-threatening disease worldwide, with high prevalence in the sub-Saharan meningitis belt. A rapid diagnosis is crucial for implementing adapted antimicrobial treatment. We describe the performances of a new immunochromatographic test (MeningoSpeed, BioSpeedia, France) for detecting and grouping Neisseria meningitidis....

    Cyrille H. Haddar, Aude Terrade, Paul Verhoeven, Berthe-Marie Njanpop-Lafourcade, Mireille Dosso, Fati Sidikou, Ali Elhaj Mahamane, Jean-Pierre Lombart, Aziza Razki, Eva Hong, Alain Agnememel, Evelyne Begaud, Yves Germani, Bruno Pozzetto, Muhamed-Kheir Taha
  • Open Access
    Reconstruction of Dispersal Patterns of Hypervirulent Meningococcal Strains of Serogroup C:cc11 by Phylogenomic Time Trees
    Bacteriology
    Reconstruction of Dispersal Patterns of Hypervirulent Meningococcal Strains of Serogroup C:cc11 by Phylogenomic Time Trees

    Neisseria meningitidis is one of the few commensal bacteria that can even cause large epidemics of invasive meningococcal disease (IMD). N. meningitis serogroup C belonging to the hypervirulent clonal complex 11 (cc11) represents an important public health threat worldwide. We reconstructed the dispersal patterns of hypervirulent meningococcal strains of...

    Alessandra Lo Presti, Arianna Neri, Cecilia Fazio, Paola Vacca, Luigina Ambrosio, Clara Grazian, Brunero Liseo, Giovanni Rezza, Martin Christopher James Maiden, Paola Stefanelli
  • Whole-Genome Sequencing for Characterization of Capsule Locus and Prediction of Serogroup of Invasive Meningococcal Isolates
    Bacteriology
    Whole-Genome Sequencing for Characterization of Capsule Locus and Prediction of Serogroup of Invasive Meningococcal Isolates

    Invasive meningococcal disease is mainly caused by Neisseria meningitidis serogroups A, B, C, X, W, and Y. The serogroup is typically determined by slide agglutination serogrouping (SASG) and real-time PCR (RT-PCR).

    Henju Marjuki, Nadav Topaz, Lorraine D. Rodriguez-Rivera, Edward Ramos, Caelin C. Potts, Alexander Chen, Adam C. Retchless, Gregory H. Doho, Xin Wang
  • Free
    Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old
    The Brief Case
    Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old
    Linda E. Brostowski, Erin H. Graf
  • Open Access
    Epidemiology
    Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine
    Luke R. Green, Jay Lucidarme, Neelam Dave, Hannah Chan, Stephen Clark, Ray Borrow, Christopher D. Bayliss
  • Point-Counterpoint
    Point-Counterpoint: Meningitis/Encephalitis Syndromic Testing in the Clinical Laboratory
    Jennifer Dien Bard, Kevin Alby
  • Open Access
    Epidemiology
    Whole-Genome Sequencing of Emerging Invasive Neisseria meningitidis Serogroup W in Sweden
    Lorraine Eriksson, Sara Thulin Hedberg, Susanne Jacobsson, Hans Fredlund, Paula Mölling, Bianca Stenmark
  • Bacteriology
    Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis
    Kevin C. Ma, Magnus Unemo, Samo Jeverica, Robert D. Kirkcaldy, Hideyuki Takahashi, Makoto Ohnishi, Yonatan H. Grad

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