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Plasmodium falciparum

  • Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections
    Parasitology
    Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections

    Microscopy and rapid diagnostic tests (RDTs) are the main diagnostic tools for malaria but fail to detect low-density parasitemias that are important for maintaining malaria transmission. To complement existing diagnostic methods, an isothermal reverse transcription-recombinase polymerase amplification and lateral flow assay (RT-RPA) was developed. We compared the performance with that of ultrasensitive reverse transcription-...

    Albert Lalremruata, The Trong Nguyen, Matthew B. B. McCall, Ghyslain Mombo-Ngoma, Selidji T. Agnandji, Ayôla A. Adegnika, Bertrand Lell, Michael Ramharter, Stephen L. Hoffman, Peter G. Kremsner, Benjamin Mordmüller
  • Evaluation of PCR To Monitor <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Treatment Efficacy in a Nonendemicity Setting
    Parasitology
    Evaluation of PCR To Monitor Plasmodium falciparum Treatment Efficacy in a Nonendemicity Setting

    Adequate clinical and parasitological response (ACPR) after malaria treatment remains challenging to assess in settings of malaria nonendemicity. Biological evaluation of parasitological clearance relies on microscopic investigation of thick blood smears, which is a specific technique that not all diagnosis laboratories are able to perform.

    Claire Kamaliddin, Valentin Joste, Véronique Hubert, Eric Kendjo, Nicolas Argy, Sandrine Houze
  • Performance of Antigen Concentration Thresholds for Attributing Fever to Malaria among Outpatients in Angola
    Parasitology
    Performance of Antigen Concentration Thresholds for Attributing Fever to Malaria among Outpatients in Angola

    The density of malaria parasites is a key determinant of whether an infected individual develops fever. While the pyrogenic threshold for malaria parasite density has been well studied, there are no analogous data on the antigen levels associated with fever during infection.

    Mateusz M. Plucinski, Eric Rogier, Pedro Rafael Dimbu, Filomeno Fortes, Eric S. Halsey, Michael Aidoo, Tom Smith
  • Open Access
    Parasitology
    Operational Performance of a Plasmodium falciparum Ultrasensitive Rapid Diagnostic Test for Detection of Asymptomatic Infections in Eastern Myanmar

    In the Greater Mekong Subregion in Southeast Asia, malaria elimination strategies need to target all Plasmodium falciparum parasites, including those carried asymptomatically. More than 70% of asymptomatic carriers are not detected by current rapid diagnostic tests (RDTs) or microscopy.

    Jordi Landier, Warat Haohankhunnatham, Smita Das, Kamonchanok Konghahong, Peter Christensen, Jathee Raksuansak, Pase Phattharakokoedbun, Ladda Kajeechiwa, May Myo Thwin, Ihn Kyung Jang, Mallika Imwong, Jacher Wiladphaingern, Khin Maung Lwin, Clare Ling, Stephane Proux, Gonzalo J. Domingo, Gilles Delmas, François H. Nosten
  • Parasitology
    Detection of Plasmodium Infection by the illumigene Malaria Assay Compared to Reference Microscopy and Real-Time PCR
    Candace Rypien, Barbara Chow, Wilson W. Chan, Deirdre L. Church, Dylan R. Pillai
  • Parasitology
    Improving the Specificity of Plasmodium falciparum Malaria Diagnosis in High-Transmission Settings with a Two-Step Rapid Diagnostic Test and Microscopy Algorithm
    Moses Murungi, Travis Fulton, Raquel Reyes, Michael Matte, Moses Ntaro, Edgar Mulogo, Dan Nyehangane, Jonathan J. Juliano, Mark J. Siedner, Yap Boum, Ross M. Boyce
  • Parasitology
    Evaluation of the Parasight Platform for Malaria Diagnosis
    Yochay Eshel, Arnon Houri-Yafin, Hagai Benkuzari, Natalie Lezmy, Mamta Soni, Malini Charles, Jayanthi Swaminathan, Hilda Solomon, Pavithra Sampathkumar, Zul Premji, Caroline Mbithi, Zaitun Nneka, Simon Onsongo, Daniel Maina, Sarah Levy-Schreier, Caitlin Lee Cohen, Dan Gluck, Joseph Joel Pollak, Seth J. Salpeter
  • Open Access
    Parasitology
    Multicenter Pivotal Clinical Trial of Urine Malaria Test for Rapid Diagnosis of Plasmodium falciparum Malaria
    Wellington A. Oyibo, Nnenna Ezeigwe, Godwin Ntadom, Oladipo O. Oladosu, Kaitlin Rainwater-Loveth, Wendy O'Meara, Evaezi Okpokoro, William Brieger
  • Parasitology
    High-Throughput Genotyping of Single Nucleotide Polymorphisms in the Plasmodium falciparum dhfr Gene by Asymmetric PCR and Melt-Curve Analysis
    Rochelle E. Cruz, Sandra E. Shokoples, Dammika P. Manage, Stephanie K. Yanow
  • Parasitology
    Reliability of Antimalarial Sensitivity Tests Depends on Drug Mechanisms of Action
    Sharon Wein, Marjorie Maynadier, Christophe Tran Van Ba, Rachel Cerdan, Suzanne Peyrottes, Laurent Fraisse, Henri Vial

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