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population genomics

  • Open Access
    Population Genomic Molecular Epidemiological Study of Macrolide-Resistant <span class="named-content genus-species" id="named-content-1">Streptococcus pyogenes</span> in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a <em>pbp2x</em> Mutation Conferring Reduced <em>In Vitro</em> β-Lactam Susceptibility
    Epidemiology
    Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced In Vitro β-Lactam Susceptibility

    Resistance to macrolide antibiotics is a global concern in the treatment of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. In Iceland, since the detection of the first macrolide-resistant isolate in 1998, three epidemic waves of macrolide-resistant GAS infections have occurred, with peaks in 1999, 2004, and 2008. We conducted whole-genome...

    Sara B. Southon, Stephen B. Beres, Priyanka Kachroo, Matthew Ojeda Saavedra, Helga Erlendsdóttir, Gunnsteinn Haraldsson, Prasanti Yerramilli, Layne Pruitt, Luchang Zhu, James M. Musser, Karl G. Kristinsson
  • Reduced <em>In Vitro</em> Susceptibility of <span class="named-content genus-species" id="named-content-1">Streptococcus pyogenes</span> to β-Lactam Antibiotics Associated with Mutations in the <em>pbp2x</em> Gene Is Geographically Widespread
    Bacteriology
    Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

    Recently, two related Streptococcus pyogenes strains with reduced susceptibility to ampicillin, amoxicillin, and cefotaxime, antibiotics commonly used to treat S. pyogenes infections, were reported. The two strains had the same nonsynonymous (amino acid-substituting) mutation in the pbp2x...

    James M. Musser, Stephen B. Beres, Luchang Zhu, Randall J. Olsen, Jaana Vuopio, Hanne-Leena Hyyryläinen, Kirsi Gröndahl-Yli-Hannuksela, Karl G. Kristinsson, Jessica Darenberg, Birgitta Henriques-Normark, Steen Hoffmann, Dominque A. Caugant, Andrew J. Smith, Diane S. J. Lindsay, David M. Boragine, Timothy Palzkill
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