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qPCR

  • Maternal Anti-<em>Toxoplasma</em> Treatment during Pregnancy Is Associated with Reduced Sensitivity of Diagnostic Tests for Congenital Infection in the Neonate
    Parasitology
    Maternal Anti-Toxoplasma Treatment during Pregnancy Is Associated with Reduced Sensitivity of Diagnostic Tests for Congenital Infection in the Neonate

    Neonatal diagnosis of congenital toxoplasmosis is based on a combination of serological and molecular tests. Maternal screening and treatment differ according to national policies and may impact the sensitivity of diagnostic methods in infants at birth.

    Hélène Guegan, Tijana Stajner, Branko Bobic, Cindy Press, Rares T. Olariu, Kjerstie Olson, Jelena Srbljanovic, Jose G. Montoya, Olgica Djurković-Djaković, Florence Robert-Gangneux
  • Diagnostic Accuracy of Interferon Gamma-Induced Protein 10 mRNA Release Assay for Tuberculosis
    Mycobacteriology and Aerobic Actinomycetes
    Diagnostic Accuracy of Interferon Gamma-Induced Protein 10 mRNA Release Assay for Tuberculosis

    Interferon gamma (IFN-γ) release assays (IGRAs) are increasingly used to test for latent tuberculosis (TB) infection. Although highly specific, IGRAs have a relatively high false-negative rate in active TB patients. A more sensitive assay is needed. IFN-γ-induced protein 10 (IP-10) is an alternative biomarker with a 100-fold-higher expression level than IFN-γ, allowing for different analysis platforms, including molecular detection. The...

    Thomas Blauenfeldt, Raquel Villar-Hernández, Esther García-García, Irene Latorre, Line Lindebo Holm, Beatriz Muriel-Moreno, Maria Luiza De Souza-Galvão, Joan Pau Millet, Fina Sabriá, Adrián Sánchez-Montalva, Juan Ruiz-Manzano, Jose Pilarte, María A. Jiménez, Carmen Centeno, Carmen Torres, Israel Molina-Pinargote, Yoel D. González-Díaz, Javier Santiago, Adela Cantos, Cristina Prat, Peter Andersen, Jose Domínguez, Morten Ruhwald
  • Open Access
    Comparison of Commercially Available and Laboratory-Developed Assays for <em>In Vitro</em> Detection of SARS-CoV-2 in Clinical Laboratories
    Special Issue Virology
    Comparison of Commercially Available and Laboratory-Developed Assays for In Vitro Detection of SARS-CoV-2 in Clinical Laboratories

    Multiple laboratory-developed tests (LDTs) and commercially available assays have emerged to meet diagnostic needs related to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To date, there is limited comparison data for these different testing platforms. We compared the analytical performance of a LDT developed in our clinical laboratory based on CDC primer sets and four commercially available, FDA emergency...

    Joshua A. Lieberman, Gregory Pepper, Samia N. Naccache, Meei-Li Huang, Keith R. Jerome, Alexander L. Greninger
  • Is Real-Time PCR Targeting Rep 529 Suitable for Diagnosis of Toxoplasmosis in Patients Infected with Non-Type II Strains in North America?
    Parasitology
    Is Real-Time PCR Targeting Rep 529 Suitable for Diagnosis of Toxoplasmosis in Patients Infected with Non-Type II Strains in North America?

    Toxoplasma gondii DNA detection is essential to antenatally diagnose a congenital infection and reactivation of a past infection in an immunocompromised patient. Initially, PCR methods targeted the 35-fold repetitive B1 gene, and more recently, coding sequence Rep 529 has been preferred, as it was reported to be repeated 200- to 300-fold and yielded far better...

    Christelle Pomares, Remy Estran, Cynthia J. Press, Aaron Bera, Raymund Ramirez, Jose G. Montoya, Florence Robert Gangneux
  • Free
    Closing the Brief Case: Inherited Chromosomally Integrated Human Herpesvirus 6 (HHV-6) in the Age of Multiplex HHV-6 Testing
    The Brief Case
    Closing the Brief Case: Inherited Chromosomally Integrated Human Herpesvirus 6 (HHV-6) in the Age of Multiplex HHV-6 Testing
    Alexander L. Greninger, Samia N. Naccache, Pia Pannaraj, Keith R. Jerome, Jennifer Dien Bard, Jeanne W. Ruderman
  • Free
    The Brief Case: Inherited Chromosomally Integrated Human Herpesvirus 6 (HHV-6) in the Age of Multiplex HHV-6 Testing
    The Brief Case
    The Brief Case: Inherited Chromosomally Integrated Human Herpesvirus 6 (HHV-6) in the Age of Multiplex HHV-6 Testing
    Alexander L. Greninger, Samia N. Naccache, Pia Pannaraj, Keith R. Jerome, Jennifer Dien Bard, Jeanne W. Ruderman
  • Molecular Diagnosis of Vaginitis: Comparing Quantitative PCR and Microbiome Profiling Approaches to Current Microscopy Scoring
    Bacteriology
    Molecular Diagnosis of Vaginitis: Comparing Quantitative PCR and Microbiome Profiling Approaches to Current Microscopy Scoring

    Vaginitis is often diagnosed by microscopy and limited to testing for bacterial vaginosis (BV), vulvovaginal candidiasis, and trichomoniasis. Approximately 10% of vaginal swabs are negative but designated “altered flora” by BV Nugent score, leaving clinicians unsure how to treat patients. Accurate and comprehensive vaginitis diagnostics are needed to direct treatment and reduce risks of recurrent or more severe infections.

    ...
    Tarah Lynch, Gisele Peirano, Tracie Lloyd, Ron Read, Julia Carter, Angel Chu, Jeffrey A. Shaman, Joseph P. Jarvis, Evan Diamond, Umer Zeeshan Ijaz, Deirdre Church
  • Letter to the Editor
    Evaluation of the SpeeDx ResistancePlus MG Diagnostic Test for Mycoplasma genitalium on the Applied Biosystems 7500 Fast Quantitative PCR Platform
    Jenny P. Su, Lit Y. Tan, Suzanne M. Garland, Sepehr N. Tabrizi, Elisa Mokany, Samantha Walker, Catriona S. Bradshaw, Tim Read, Gerald L. Murray
  • Bacteriology
    Molecular Tests That Target the RTX Locus Do Not Distinguish between Kingella kingae and the Recently Described Kingella negevensis Species
    Nawal El Houmami, Janek Bzdrenga, Guillaume André Durand, Philippe Minodier, Hervé Seligmann, Elsa Prudent, Sofiane Bakour, Stéphane Bonacorsi, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
  • Bacteriology
    A Single Negative Result for van Quantitative PCR on Enrichment Broth Can Replace Five Rectal Swab Cultures in Screening for Vancomycin-Resistant Enterococci
    J. M. Fonville, C. M. C. van Herk, P. H. A. C. Das, J. H. B. van de Bovenkamp, L. van Dommelen

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