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SARS-CoV-2

  • Free
    Saliva Is a Promising Alternative Specimen for the Detection of SARS-CoV-2 in Children and Adults
    Virology
    Saliva Is a Promising Alternative Specimen for the Detection of SARS-CoV-2 in Children and Adults

    Testing efforts for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been burdened by the scarcity of testing materials and personal protective equipment for health care workers. The simple and painless process of saliva collection allows for widespread testing, but enthusiasm is hampered by variable performance compared to that of nasopharyngeal swab (NPS) samples.

    Rebecca Yee, Thao T. Truong, Pia S. Pannaraj, Natalie Eubanks, Emily Gai, Jaycee Jumarang, Lauren Turner, Ariana Peralta, Yesun Lee, Jennifer Dien Bard
  • Free
    A Multiplex Microsphere IgG Assay for SARS-CoV-2 Using ACE2-Mediated Inhibition as a Surrogate for Neutralization
    Immunoassays
    A Multiplex Microsphere IgG Assay for SARS-CoV-2 Using ACE2-Mediated Inhibition as a Surrogate for Neutralization

    The coronavirus disease 2019 (COVID-19) pandemic has highlighted the challenges inherent to the serological detection of a novel pathogen such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Serological tests can be used diagnostically and for surveillance, but their usefulness depends on their throughput, sensitivity, and specificity. Here, we describe a multiplex fluorescent microsphere-based assay, 3Flex, that can...

    Andrew Cameron, Claire A. Porterfield, Larry D. Byron, Jiong Wang, Zachary Pearson, Jessica L. Bohrhunter, Anthony B. Cardillo, Lindsay Ryan-Muntz, Ryan A. Sorensen, Mary T. Caserta, Stephen Angeloni, Dwight J. Hardy, Martin S. Zand, Nicole D. Pecora
  • Free
    Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera
    Immunoassays
    Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera

    Surrogate neutralization assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be done without biosafety level 3 containment and in multiple species are desirable. We evaluate a recently developed surrogate virus neutralization test (sVNT) in comparison to 90% plaque reduction neutralization tests (PRNT90) in human, canine, cat, and hamster sera. With PRNT90 as the reference, sVNT had...

    Ranawaka A. P. M. Perera, Ronald Ko, Owen T. Y. Tsang, David S. C. Hui, Mike Y. M. Kwan, Christopher J. Brackman, Esther M. W. To, Hui-ling Yen, Kathy Leung, Samuel M. S. Cheng, Kin Ho Chan, Karl C. K. Chan, Ka-Chi Li, Linda Saif, Vanessa R. Barrs, Joseph T. Wu, Thomas H. C. Sit, Leo L. M. Poon, Malik Peiris
  • Free
    Inference of Active Viral Replication in Cases with Sustained Positive Reverse Transcription-PCR Results for SARS-CoV-2
    Virology
    Inference of Active Viral Replication in Cases with Sustained Positive Reverse Transcription-PCR Results for SARS-CoV-2

    The purpose of this study was to detect coronavirus disease 2019 (COVID-19) cases with persistent positive reverse transcription-PCR (RT-PCR) results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which viable virus can be inferred due to the presence of subgenomic (SG) viral RNA, which is expressed only in replicating viruses. RNA remnants purified from diagnostic nasopharyngeal specimens were used as the...

    Cristina Rodríguez-Grande, Javier Adán-Jiménez, Pilar Catalán, Luis Alcalá, Agustín Estévez, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma
    and on behalf of the Gregorio Marañón Microbiology-ID COVID-19 Study Group
  • Free
    Detection of SARS-CoV-2 Antibodies in Oral Fluid Obtained Using a Rapid Collection Device
    Immunoassays
    Detection of SARS-CoV-2 Antibodies in Oral Fluid Obtained Using a Rapid Collection Device

    Current commercially available methods for reliably detecting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain expensive and inaccessible due to the need for whole-blood collection by highly trained phlebotomists using personal protective equipment (PPE). We have evaluated an antibody detection approach using the OraSure Technologies oral antibody collection device (OACD) and their proprietary SARS-...

    Melanie A. MacMullan, Prithivi Chellamuthu, Aubree Mades, Sudipta Das, Fred Turner, Vladimir I. Slepnev, Albina Ibrayeva
  • Free
    Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers
    Virology
    Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers

    Accurate serological assays to detect antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to characterize the epidemiology of SARS-CoV-2 infection and identify potential candidates for coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) donation. This study compared the performances of commercial enzyme immunoassays (EIAs) with respect to detection of IgG or total antibodies to SARS-CoV-2 and...

    Eshan U. Patel, Evan M. Bloch, William Clarke, Yu-Hsiang Hsieh, Denali Boon, Yolanda Eby, Reinaldo E. Fernandez, Owen R. Baker, Morgan Keruly, Charles S. Kirby, Ethan Klock, Kirsten Littlefield, Jernelle Miller, Haley A. Schmidt, Philip Sullivan, Estelle Piwowar-Manning, Ruchee Shrestha, Andrew D. Redd, Richard E. Rothman, David Sullivan, Shmuel Shoham, Arturo Casadevall, Thomas C. Quinn, Andrew Pekosz, Aaron A. R. Tobian, Oliver Laeyendecker
  • Free
    Comparison of the Quidel Sofia SARS FIA Test to the Hologic Aptima SARS-CoV-2 TMA Test for Diagnosis of COVID-19 in Symptomatic Outpatients
    Virology
    Comparison of the Quidel Sofia SARS FIA Test to the Hologic Aptima SARS-CoV-2 TMA Test for Diagnosis of COVID-19 in Symptomatic Outpatients

    The Quidel Sofia severe acute respiratory syndrome (SARS) fluorescent immunoassay (FIA) test (SOFIA) is a rapid antigen immunoassay for the detection of SARS coronavirus 2 (SARS-CoV-2) proteins from nasal or nasopharyngeal swab specimens. The purpose of this study was to compare the results of the SOFIA test to those of the Hologic Aptima SARS-CoV-2 TMA test (APTIMA TMA), a high-throughput molecular diagnostic test that uses...

    Eric T. Beck, Wendy Paar, Lara Fojut, Jordan Serwe, Renee R. Jahnke
  • Free
    Evaluation of the Panbio COVID-19 Rapid Antigen Detection Test Device for the Screening of Patients with COVID-19
    Letter to the Editor
    Evaluation of the Panbio COVID-19 Rapid Antigen Detection Test Device for the Screening of Patients with COVID-19
    Florence Fenollar, Amar Bouam, Mehdi Ballouche, Léa Fuster, Elsa Prudent, Philippe Colson, Hervé Tissot-Dupont, Matthieu Million, Michel Drancourt, Didier Raoult, Pierre-Edouard Fournier
  • Free
    Evaluating 10 Commercially Available SARS-CoV-2 Rapid Serological Tests by Use of the STARD (Standards for Reporting of Diagnostic Accuracy Studies) Method
    Immunoassays
    Evaluating 10 Commercially Available SARS-CoV-2 Rapid Serological Tests by Use of the STARD (Standards for Reporting of Diagnostic Accuracy Studies) Method

    Numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce. In this study, we evaluated and compared 10 commercially available SARS-CoV-2 rapid serological tests using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) methodology.

    ...
    Laurent Dortet, Jean-Baptiste Ronat, Christelle Vauloup-Fellous, Céline Langendorf, David-Alexis Mendels, Cécile Emeraud, Saoussen Oueslati, Delphine Girlich, Anthony Chauvin, Ali Afdjei, Sandrine Bernabeu, Samuel Le Pape, Rim Kallala, Alice Rochard, Celine Verstuyft, Nicolas Fortineau, Anne-Marie Roque-Afonso, Thierry Naas
  • Free
    Extraction-Free Methods for the Detection of SARS-CoV-2 by Reverse Transcription-PCR: a Comparison with the Cepheid Xpert Xpress SARS-CoV-2 Assay across Two Medical Centers
    Letter to the Editor
    Extraction-Free Methods for the Detection of SARS-CoV-2 by Reverse Transcription-PCR: a Comparison with the Cepheid Xpert Xpress SARS-CoV-2 Assay across Two Medical Centers
    Andrew Cameron, Nicole D. Pecora, Matthew A. Pettengill

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