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Journal of Clinical Microbiology
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Staphylococcus aureus

  • Global Epidemiology and Evolutionary History of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> ST45
    Epidemiology
    Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45

    Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451...

    N. Effelsberg, M. Stegger, L. Peitzmann, O. Altinok, G. W. Coombs, B. Pichon, A. Kearns, P. R. Randad, C. D. Heaney, S. Bletz, F. Schaumburg, A. Mellmann
  • Development of a Novel and Rapid Antibody-Based Diagnostic for Chronic <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Infections Based on Biofilm Antigens
    Immunoassays
    Development of a Novel and Rapid Antibody-Based Diagnostic for Chronic Staphylococcus aureus Infections Based on Biofilm Antigens

    Prosthetic joint infections are difficult to diagnose and treat due to biofilm formation by the causative pathogens. Pathogen identification relies on microbial culture that requires days to weeks, and in the case of chronic biofilm infections, lacks sensitivity. Diagnosis of infection is often delayed past the point of effective treatment such that only the removal of the implant is curative. Early diagnosis of an infection based on...

    Janette M. Harro, Mark E. Shirtliff, William Arnold, Jennifer M. Kofonow, Chad Dammling, Yvonne Achermann, Kristen Brao, Javad Parvizi, Jeff G. Leid
  • Difficult-To-Detect <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>: <em>mecA</em>-Positive Isolates Associated with Oxacillin and Cefoxitin False-Susceptible Results
    Letter to the Editor
    Difficult-To-Detect Staphylococcus aureus: mecA-Positive Isolates Associated with Oxacillin and Cefoxitin False-Susceptible Results
    Amy S. Gargis, Brian B. Yoo, David R. Lonsway, Karen Anderson, Davina Campbell, Thomas O. Ewing, Adrian Lawsin, María-José Machado, Norihisa Yamamoto, Alison Laufer Halpin, Joseph D. Lutgring, Maria Karlsson, J. Kamile Rasheed, Christopher A. Elkins
  • Genotypic Characterization of Livestock-Associated Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Isolates of Clonal Complex 398 in Pigsty Visitors: Transient Carriage or Persistence?
    Epidemiology
    Genotypic Characterization of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Isolates of Clonal Complex 398 in Pigsty Visitors: Transient Carriage or Persistence?

    Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) of clonal complex (CC) 398 has become a rising issue for public health. While it is known that >80% of pig farmers are colonized with LA-MRSA, only a few studies have assessed the situation for humans with occasional livestock contact. Recently it was shown that over 75% of scientific...

    N. Effelsberg, S. Udarcev, H. Müller, I. Kobusch, S. Linnemann, M. Boelhauve, R. Köck, A. Mellmann
  • Performance of the BD Phoenix Automated Microbiology System for Trimethoprim-Sulfamethoxazole Susceptibility Testing of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Letter to the Editor
    Performance of the BD Phoenix Automated Microbiology System for Trimethoprim-Sulfamethoxazole Susceptibility Testing of Staphylococcus aureus
    Ghada N. Al-Rawahi, Sam Chorlton, Sukhvinder Dhaliwal, George R. Golding, Peter Tilley
  • Performance of the Revised Version of an Immunochromatographic Assay for Detection of <em>mecA</em>- and <em>mecC</em>-Mediated Methicillin Resistance in Staphylococci
    Letter to the Editor
    Performance of the Revised Version of an Immunochromatographic Assay for Detection of mecA- and mecC-Mediated Methicillin Resistance in Staphylococci
    Céline Dupieux, William Mouton, Camille André, François Vandenesch, Michèle Bes, Anne Tristan, Frédéric Laurent
  • Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> in Hospitals: Latest Trends and Treatments Based on Bacteriophages
    Minireview
    Methicillin-Resistant Staphylococcus aureus in Hospitals: Latest Trends and Treatments Based on Bacteriophages

    Even though antibiotic resistance in bacteria is a natural phenomenon, the alarming increase in pathogenic bacteria refractory to a wide range of antimicrobials is attracting attention worldwide. Indeed, the World Health Organization (WHO) has recently published a list of priority pathogens for which new antimicrobial alternatives are urgently needed. Among these pathogens, methicillin-resistant...

    Andrea Álvarez, Lucía Fernández, Diana Gutiérrez, Beatriz Iglesias, Ana Rodríguez, Pilar García
  • Open Access
    Pilot Evaluation of a Fully Automated Bioinformatics System for Analysis of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Genomes and Detection of Outbreaks
    Bacteriology
    Pilot Evaluation of a Fully Automated Bioinformatics System for Analysis of Methicillin-Resistant Staphylococcus aureus Genomes and Detection of Outbreaks

    Genomic surveillance that combines bacterial sequencing and epidemiological information will become the gold standard for outbreak detection, but its clinical translation is hampered by the lack of automated interpretation tools. We performed a prospective pilot study to evaluate the analysis of methicillin-resistant Staphylococcus aureus (MRSA) genomes using the Next...

    Nicholas M. Brown, Beth Blane, Kathy E. Raven, Narender Kumar, Danielle Leek, Eugene Bragin, Paul A. Rhodes, David A. Enoch, Rachel Thaxter, Julian Parkhill, Sharon J. Peacock
  • Free
    Bacteriology
    Accuracy of Different Bioinformatics Methods in Detecting Antibiotic Resistance and Virulence Factors from Staphylococcus aureus Whole-Genome Sequences
    Amy Mason, Dona Foster, Phelim Bradley, Tanya Golubchik, Michel Doumith, N. Claire Gordon, Bruno Pichon, Zamin Iqbal, Peter Staves, Derrick Crook, A. Sarah Walker, Angela Kearns, Tim Peto
  • Commentary
    “Pathogen Eradication” and “Emerging Pathogens”: Difficult Definitions in Cystic Fibrosis
    Peter H. Gilligan, Damian G. Downey, J. Stuart Elborn, Patrick A. Flume, Sebastian Funk, Deirdre Gilpin, Timothy J. Kidd, John McCaughan, B. Cherie Millar, Philip G. Murphy, Jacqueline C. Rendall, Michael M. Tunney, John E. Moore

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