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syphilis

  • Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017
    Epidemiology
    Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017

    Discordant syphilis test results, with a reactive nontreponemal test and nonreactive treponemal test are usually considered biological false-positive test results (BFPs), which can be attributed to other conditions. Syphilis surveillance laws mandate laboratory reporting of reactive syphilis tests, which include many BFPs. We describe the frequency of BFPs, titer distributions, and titer increases from reported test results in Florida...

    James Matthias, Ellen J. Klingler, Julia A. Schillinger, Gayle Keller, Craig Wilson, Thomas A. Peterman
  • High Agreement of the BioPlex 2200 Syphilis Total & RPR Assay with the Confirmatory Treponemal Test on Weak Positive Screening Samples
    Letter to the Editor
    High Agreement of the BioPlex 2200 Syphilis Total & RPR Assay with the Confirmatory Treponemal Test on Weak Positive Screening Samples
    Emilie De Maertelaere, Casper Van den Borre, Sara Bourgois, Marjan Van Esbroeck, Sandra Deridder, Sofie Blomme, Elizaveta Padalko
  • <em>Treponema pallidum</em> Nucleic Acid Amplification Testing To Augment Syphilis Screening among Men Who Have Sex with Men
    Bacteriology
    Treponema pallidum Nucleic Acid Amplification Testing To Augment Syphilis Screening among Men Who Have Sex with Men

    Syphilis rates in much of the world are now at their highest levels in almost three decades, and new approaches to controlling syphilis, including diagnostic tests with shorter window periods, are urgently needed.

    Matthew Golden, Meghan O’Donnell, Sheila Lukehart, Paul Swenson, Paul Hovey, Charmie Godornes, Sarah Romano, Damon Getman
  • Molecular Typing and Macrolide Resistance Analyses of <span class="named-content genus-species" id="named-content-1">Treponema pallidum</span> in Heterosexuals and Men Who Have Sex with Men in Japan, 2017
    Epidemiology
    Molecular Typing and Macrolide Resistance Analyses of Treponema pallidum in Heterosexuals and Men Who Have Sex with Men in Japan, 2017

    In recent years, syphilis notifications have increased dramatically in Japan. We carried out molecular typing and macrolide resistance analyses of Treponema pallidum subsp.

    Mizue Kanai, Yuzo Arima, Shingo Nishiki, Ken Shimuta, Ichiro Itoda, Tamano Matsui, Kazunori Oishi, Makoto Ohnishi, Shu-ichi Nakayama
  • Clinical Performance of the BioPlex 2200 Syphilis Total &amp; RPR Assay at a Tertiary Medical Center with a High Rate of Syphilis
    Immunoassays
    Clinical Performance of the BioPlex 2200 Syphilis Total & RPR Assay at a Tertiary Medical Center with a High Rate of Syphilis

    Manual treponemal and nontreponemal serologic testing has historically been used for the diagnosis of syphilis. This approach is simple and reproducible but labor intensive.

    Merih T. Tesfazghi, Neil W. Anderson, Ann M. Gronowski, Melanie L. Yarbrough
  • Circulation of Distinct <em>Treponema pallidum</em> Strains in Individuals with Heterosexual Orientation and Men Who Have Sex with Men
    Epidemiology
    Circulation of Distinct Treponema pallidum Strains in Individuals with Heterosexual Orientation and Men Who Have Sex with Men

    Human treponematosis is caused by various pathogenic Treponema pallidum subspecies, including T. pallidum subsp. pallidum, T. pallidum subsp.

    ...
    Yoko Kojima, Keiichi Furubayashi, Takuya Kawahata, Haruyo Mori, Jun Komano
  • Usefulness of Automated Latex Turbidimetric Rapid Plasma Reagin Test for Diagnosis and Evaluation of Treatment Response in Syphilis in Comparison with Manual Card Test: a Prospective Cohort Study
    Bacteriology
    Usefulness of Automated Latex Turbidimetric Rapid Plasma Reagin Test for Diagnosis and Evaluation of Treatment Response in Syphilis in Comparison with Manual Card Test: a Prospective Cohort Study

    The usefulness of an automated latex turbidimetric rapid plasma reagin (RPR) assay, compared to the conventional manual card test (serial 2-fold dilution method), for the diagnosis of syphilis and evaluation of treatment response remains unknown. We conducted (i) a cross-sectional study and (ii) a prospective cohort study to elucidate the correlation between automated and manual tests and whether a 4-fold decrement is a feasible...

    Motoyuki Tsuboi, Takeshi Nishijima, Takahiro Aoki, Katsuji Teruya, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
  • Open Access
    Laboratory Evaluation of a Commercially Available Rapid Syphilis Test
    Immunoassays
    Laboratory Evaluation of a Commercially Available Rapid Syphilis Test

    Serological diagnosis of syphilis depends on assays that detect treponemal and nontreponemal antibodies. Laboratory certification and trained personnel are needed to perform most of these tests, while high costs and long turnaround time can hinder treatment initiation or linkage to care.

    Lara E. Pereira, Joshua McCormick, Tandin Dorji, Joseph Kang, Yongcheng Sun, Mayur Shukla, Andre Hopkins, John Deutsch, Ellen N. Kersh, Kyle Bernstein, Yetunde F. Fakile
  • Letter to the Editor
    Analytical Comparison of the Architect Syphilis TP and Liaison Treponema Automated Chemiluminescent Immunoassays and Their Performance in a Reverse Syphilis Screening Algorithm
    Alan M. Sanfilippo, Kristie Freeman, John L. Schmitz
  • Immunoassays
    Comparison of Manual and Fully Automated AIX1000 Rapid Plasma Reagin Assays for Laboratory Diagnosis of Syphilis

    The analytical performance of the AIX1000 system, a fully automated and recently FDA-cleared rapid plasma reagin (RPR) system, was evaluated by comparison to a manual RPR test in a traditional syphilis testing algorithm. A total of 1,028 consecutive serum samples submitted for syphilis testing to the University of North Carolina Hospitals Clinical Immunology Laboratory were tested per each manufacturer's instructions.

    ...
    Alan M. Sanfilippo, Kristie Freeman, John L. Schmitz

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