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Journal of Clinical Microbiology
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tuberculous meningitis

  • Open Access
    Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches
    Minireview
    Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches

    Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing high mortality or disability. Clinical management of the disease is challenging due to limitations of the existing diagnostic approaches. Our knowledge on the immunology and pathogenesis of the disease is currently limited. More research is urgently needed to enhance our understanding of the immunopathogenesis of the disease and guide us toward the...

    Charles M. Manyelo, Regan S. Solomons, Gerhard Walzl, Novel N. Chegou
  • Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> Infection and Predominance of Lineage 4
    Mycobacteriology and Aerobic Actinomycetes
    Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4

    Tuberculous meningitis (TBM), the most severe extrapulmonary manifestation of tuberculosis, is caused by the pathogen Mycobacterium tuberculosis. The M. tuberculosis complex includes seven lineages, all described to harbor a unique geographical dissemination pattern and clinical presentation. In...

    L. M. van Leeuwen, P. Versteegen, S. D. Zaharie, S. L. van Elsland, A. Jordaan, E. M. Streicher, R. M. Warren, M. van der Kuip, A. M. van Furth
  • Prospective Cohort Study on Performance of Cerebrospinal Fluid (CSF) Xpert MTB/RIF, CSF Lipoarabinomannan (LAM) Lateral Flow Assay (LFA), and Urine LAM LFA for Diagnosis of Tuberculous Meningitis in Zambia
    Mycobacteriology and Aerobic Actinomycetes
    Prospective Cohort Study on Performance of Cerebrospinal Fluid (CSF) Xpert MTB/RIF, CSF Lipoarabinomannan (LAM) Lateral Flow Assay (LFA), and Urine LAM LFA for Diagnosis of Tuberculous Meningitis in Zambia

    Tuberculous meningitis (TBM) is a devastating infection of the central nervous system lacking an adequate point-of-care diagnostic test. We conducted a prospective cohort study of 550 Zambian adults with suspected TBM to determine the diagnostic accuracy of cerebrospinal fluid (CSF) Xpert MTB/RIF, CSF lipoarabinomannan (LAM), urine LAM, CSF total protein, and CSF glucose compared with the gold standard of CSF culture.

    ...
    Omar K. Siddiqi, Gretchen L. Birbeck, Musie Ghebremichael, Eugene Mubanga, Shawn Love, Clayton Buback, Barry Kosloff, Helen Ayles, Masharip Atadzhanov, Keertan Dheda, Igor J. Koralnik
  • A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Nucleic Acid Amplification Tests for Tuberculous Meningitis
    Minireview
    A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Nucleic Acid Amplification Tests for Tuberculous Meningitis

    The diagnosis of tuberculous meningitis (TBM) is difficult and poses a significant challenge to physicians worldwide. Recently, nucleic acid amplification (NAA) tests have shown promise for the diagnosis of TBM, although their performance has been variable.

    Ali Pormohammad, Mohammad Javad Nasiri, Timothy D. McHugh, Seyed Mohammad Riahi, Nathan C. Bahr
  • Xpert MTB/RIF Ultra for Detection of <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> in Cerebrospinal Fluid
    Letter to the Editor
    Xpert MTB/RIF Ultra for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid
    Jerome H. Chin, Abdu K. Musubire, Nicole Morgan, Jacob Pellinen, Scott Grossman, Jaydeep M. Bhatt, Vincent Wadda, Willy Ssengooba
  • A Simple Microfluidic Assay for Diagnosing Tuberculous Meningitis in HIV-Uninfected Patients
    Mycobacteriology and Aerobic Actinomycetes
    A Simple Microfluidic Assay for Diagnosing Tuberculous Meningitis in HIV-Uninfected Patients

    We evaluated the diagnostic performance of a simple and label-free pathogen enrichment method using homobifunctional imidoesters (HI) and a microfluidic system, called the SLIM assay, followed by real-time PCR from cerebrospinal fluid (CSF) in human immunodeficiency virus (HIV)-uninfected patients with suspected...

    Joung Ha Park, Choong Eun Jin, Bonhan Koo, Ji-Soo Kwon, Hye Hee Cha, Ji Yeun Kim, Geun Su Noh, Yong Seo Koo, Sang-Beom Jeon, Sang-Ahm Lee, Yong Shin, Sung-Han Kim
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