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Journal of Clinical Microbiology
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Latest Articles

  • Epidemiology
    Cross-border emergence of Escherichia coli producing the carbapenemase NDM-5 in Switzerland and Germany
    Trinad Chakraborty, Mustafa Sadek, Yancheng Yao, Can Imirzalioglu, Roger Stephan, Laurent Poirel, Patrice Nordmann
  • Open Access
    Virology
    Study to evaluate the performance of a point-of-care whole blood HIV viral load test (SAMBA II HIV-1 Semi-Q Whole Blood).
    Gary Brook, Tetiana Stepchenkova, Innocent M. Ali, Sandra Chipuka, Neha Goel, Helen Lee
  • Free
    Comparison of Upper Respiratory Viral Load Distributions in Asymptomatic and Symptomatic Children Diagnosed with SARS-CoV-2 Infection in Pediatric Hospital Testing Programs
    Virology
    Comparison of Upper Respiratory Viral Load Distributions in Asymptomatic and Symptomatic Children Diagnosed with SARS-CoV-2 Infection in Pediatric Hospital Testing Programs

    The distribution of upper respiratory viral loads (VL) in asymptomatic children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We assessed PCR cycle threshold (Ct) values and estimated VL in infected asymptomatic children diagnosed in nine pediatric hospital testing programs. Records for asymptomatic and symptomatic patients with positive clinical SARS-CoV-2 tests were reviewed. Ct values were (i...

    Larry K. Kociolek, William J. Muller, Rebecca Yee, Jennifer Dien Bard, Cameron A. Brown, Paula A. Revell, Hanna Wardell, Timothy J. Savage, Sarah Jung, Samuel Dominguez, Bijal A. Parikh, Robert C. Jerris, Sue C. Kehl, Aaron Campigotto, Jeffrey M. Bender, Xiaotian Zheng, Emily Muscat, Matthew Linam, Lisa Abuogi, Christiana Smith, Kelly Graff, Ariel Hernandez-Leyva, David Williams, Nira R. Pollock
  • Free
    When Should Asymptomatic Persons Be Tested for COVID-19?
    Editorial
    When Should Asymptomatic Persons Be Tested for COVID-19?

    On 24 August 2020, the Centers for Disease Control and Prevention (CDC) updated its website to highlight that asymptomatic individuals, even those with exposure to a COVID-19-positive contact, do not necessarily need to be tested unless they have medical conditions associated with increased risk of severe illness from COVID-19. The CDC subsequently updated its guidance on 19 September 2020 to support testing of asymptomatic persons,...

    Audrey N. Schuetz, Peera Hemarajata, Ninad Mehta, Sheldon Campbell, Stephanie Mitchell, Elizabeth Palavecino, Susan Butler-Wu, Melissa B. Miller
  • Open Access
    Identification of a Polymorphism in the N Gene of SARS-CoV-2 That Adversely Impacts Detection by Reverse Transcription-PCR
    Letter to the Editor
    Identification of a Polymorphism in the N Gene of SARS-CoV-2 That Adversely Impacts Detection by Reverse Transcription-PCR
    Manu Vanaerschot, Sabrina A. Mann, James T. Webber, Jack Kamm, Sidney M. Bell, John Bell, Si Noon Hong, Minh Phuong Nguyen, Lienna Y. Chan, Karan D. Bhatt, Michelle Tan, Angela M. Detweiler, Alex Espinosa, Wesley Wu, Joshua Batson, David Dynerman, Debra A. Wadford, Andreas S. Puschnik, Norma Neff, Vida Ahyong, Steve Miller, Patrick Ayscue, Cristina M. Tato, Simon Paul, Amy L. Kistler, Joseph L. DeRisi, Emily D. Crawford
  • Novel Strategy for Rapidly and Safely Distinguishing <span class="named-content genus-species" id="named-content-1">Bacillus anthracis</span> and <span class="named-content genus-species" id="named-content-2">Bacillus cereus</span> by Use of Peptide Mass Fingerprints Based on Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry
    Bacteriology
    Novel Strategy for Rapidly and Safely Distinguishing Bacillus anthracis and Bacillus cereus by Use of Peptide Mass Fingerprints Based on Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

    The objective of this study was to construct a rapid, high-throughput, and biosafety-compatible screening method for Bacillus anthracis and Bacillus cereus based on matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). MALDI-TOF MS coupled to ClinProTools was...

    Jianchun Wei, Huijuan Zhang, Huifang Zhang, Enmin Zhang, Binghua Zhang, Fei Zhao, Di Xiao
  • Open Access
    Clinical Evaluation of BD Veritor SARS-CoV-2 Point-of-Care Test Performance Compared to PCR-Based Testing and versus the Sofia 2 SARS Antigen Point-of-Care Test
    Virology
    Clinical Evaluation of BD Veritor SARS-CoV-2 Point-of-Care Test Performance Compared to PCR-Based Testing and versus the Sofia 2 SARS Antigen Point-of-Care Test

    The clinical performance of the BD Veritor System for Rapid Detection of SARS-CoV-2 nucleocapsid antigen (Veritor), a chromatographic immunoassay used for SARS-CoV-2 point-of-care testing, was evaluated using nasal specimens from individuals with COVID-19 symptoms. Two studies were completed to determine clinical performance. In the first study, nasal specimens and either nasopharyngeal or oropharyngeal specimens from 251 participants...

    Stephen Young, Stephanie N. Taylor, Catherine L. Cammarata, Katey G. Varnado, Celine Roger-Dalbert, Amanda Montano, Christen Griego-Fullbright, Cameron Burgard, Catherine Fernandez, Karen Eckert, Jeffrey C. Andrews, Huimiao Ren, Joseph Allen, Ronald Ackerman, Charles K. Cooper
  • Open Access
    Diagnostic Accuracy of the Biosynex CryptoPS Cryptococcal Antigen Semiquantitative Lateral Flow Assay in Patients with Advanced HIV Disease
    Mycology
    Diagnostic Accuracy of the Biosynex CryptoPS Cryptococcal Antigen Semiquantitative Lateral Flow Assay in Patients with Advanced HIV Disease

    High cryptococcal antigen (CrAg) titers in blood are associated with subclinical meningitis and mortality in CrAg-positive individuals with advanced HIV disease (AHD). We evaluated a novel semiquantitative lateral flow assay (LFA), CryptoPS, that may be able to identify individuals with high CrAg titers in a cohort of AHD patients undergoing CrAg screening. In a prospective cohort of patients with AHD (CD4 cell count, ≤200/μl) receiving...

    Mark W. Tenforde, Timothée Boyer-Chammard, Charles Muthoga, Leabaneng Tawe, Thandi Milton, Ikanyeng Rulaganyang, Kwana Lechiile, Ivy Rukasha, Tshepo B. Leeme, Nelesh P. Govender, Julia Ngidi, Madisa Mine, Síle F. Molloy, Thomas S. Harrison, Olivier Lortholary, Joseph N. Jarvis
  • MIC Ranges of Quality Control Strain <span class="named-content genus-species" id="named-content-1">Mycobacterium peregrinum</span> ATCC 700686 against Rifabutin, Eravacycline, Delafloxacin, Clofazimine, and Bedaquiline
    Letter to the Editor
    MIC Ranges of Quality Control Strain Mycobacterium peregrinum ATCC 700686 against Rifabutin, Eravacycline, Delafloxacin, Clofazimine, and Bedaquiline
    Matilda Boey, Zhehao Liu, Jeanette Teo, Sophie Octavia, Bintou A. Ahidjo, Ka Lip Chew
  • HIV-2 Drug Resistance Genotyping from Dried Blood Spots
    Virology
    HIV-2 Drug Resistance Genotyping from Dried Blood Spots

    The treatment of HIV-2 in resource-limited settings (RLS) is complicated by the limited availability of HIV-2-active antiretroviral drugs and inadequate access to HIV-2 viral load and drug resistance testing. Dried blood spots (DBS)-based drug resistance testing, widely studied for HIV-1, has not been reported for HIV-2 and could present an opportunity to improve care for HIV-2-infected individuals. We selected 150 DBS specimens from...

    Dana N. Raugi, Robert S. Nixon, Sally Leong, Khadim Faye, Jean Phillipe Diatta, Fatima Sall, Robert A. Smith, ElHadji Ibrahima Sall, Jean Jacques Malomar, Moussa Seydi, Geoffrey S. Gottlieb
    and for the University of Washington-Senegal HIV-2 Research Group

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Journal of Clinical Microbiology® (JCM) publishes the most current research related to the laboratory diagnosis of human and animal infections and the role of the laboratory in both the management of infectious diseases and the elucidation of the epidemiology of infections.

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