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Journal of Clinical Microbiology
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Latest Articles

  • Bacteriology
    Antimicrobial Susceptibility Profiles to Predict the Presence of Carbapenemase Genes among Carbapenem-Resistant Pseudomonas aeruginosa
    Snigdha Vallabhaneni, Jennifer Y. Huang, Julian E. Grass, Amelia Bhatnagar, Sarah Sabour, Joseph D. Lutgring, Davina Campbell, Maria Karlsson, Alexander J. Kallen, Elizabeth Nazarian, Emily A. Snavely, Shannon Morris, Chun Wang, Rachel Lee, Myong Koag, Robert Lewis, Bobbiejean Garcia, EIP Work Group, Allison C. Brown, Maroya Spalding Walters
  • Free
    Letter to the Editor
    Evaluations of SARS-CoV-2 serological assays performance need inclusion of long-term samples
    Julien Favresse, Jonathan Douxfils
  • Free
    Performance Characteristics of BinaxNOW COVID-19 Antigen Card for Screening Asymptomatic Individuals in a University Setting
    Virology
    Performance Characteristics of BinaxNOW COVID-19 Antigen Card for Screening Asymptomatic Individuals in a University Setting

    We compared the performance of the Abbott BinaxNOW COVID-19 antigen card to that of a standard reverse transcription-PCR (RT-PCR) assay (Thermo Fisher TaqPath COVID-19 Combo kit) for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2,645 asymptomatic students presenting for screening at the University of Utah. SARS-CoV-2 RNA was detected in 1.7% of the study participants by RT-PCR.

    Nkemakonam C. Okoye, Adam P. Barker, Kenneth Curtis, Richard R. Orlandi, Emily A. Snavely, Cameron Wright, Kimberly E. Hanson, Lauren N. Pearson
  • Free
    A Novel Point Mutation in the N Gene of SARS-CoV-2 May Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR
    Letter to the Editor
    A Novel Point Mutation in the N Gene of SARS-CoV-2 May Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR
    Mohammad Rubayet Hasan, Sathyavathi Sundararaju, Chidambaram Manickam, Faheem Mirza, Hamad Al-Hail, Stephan Lorenz, Patrick Tang
  • Performance of Two Novel Chromogenic Media for the Identification of Multidrug-Resistant <span class="named-content genus-species" id="named-content-1">Candida auris</span> Compared with Other Commercially Available Formulations
    Mycology
    Performance of Two Novel Chromogenic Media for the Identification of Multidrug-Resistant Candida auris Compared with Other Commercially Available Formulations

    Non-albicans Candida species are emerging in the nosocomial environment, with the multidrug-resistant (MDR) species Candida auris being the most notorious example. Consequently, rapid and accurate species identification has become essential.

    Auke W. de Jong, Chendo Dieleman, Mauricio Carbia, Ratna Mohd Tap, Ferry Hagen
  • Comparing BioFire FilmArray BCID2 and BCID Panels for Direct Detection of Bacterial Pathogens and Antimicrobial Resistance Genes from Positive Blood Cultures
    Letter to the Editor
    Comparing BioFire FilmArray BCID2 and BCID Panels for Direct Detection of Bacterial Pathogens and Antimicrobial Resistance Genes from Positive Blood Cultures
    Venere Cortazzo, Tiziana D’Inzeo, Liliana Giordano, Giulia Menchinelli, Flora Marzia Liotti, Barbara Fiori, Flavio De Maio, Francesco Luzzaro, Maurizio Sanguinetti, Brunella Posteraro, Teresa Spanu
  • Free
    Quantitative Measurement of Anti-SARS-CoV-2 Antibodies: Analytical and Clinical Evaluation
    Immunoassays
    Quantitative Measurement of Anti-SARS-CoV-2 Antibodies: Analytical and Clinical Evaluation

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). While molecular-based testing is used to diagnose COVID-19, serologic testing of antibodies specific to SARS-CoV-2 is used to detect past infection.

    Victoria Higgins, Anselmo Fabros, Vathany Kulasingam
  • Free
    Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay
    Virology
    Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay

    Diagnosis of COVID-19 by PCR offers high sensitivity, but the utility of detecting samples with high cycle threshold (CT) values remains controversial. Currently available rapid diagnostic tests (RDTs) for SARS-CoV-2 nucleocapsid antigens (Ag) have sensitivity well below PCR.

    Nira R. Pollock, Timothy J. Savage, Hanna Wardell, Rose A. Lee, Anu Mathew, Martin Stengelin, George B. Sigal
  • Free
    Performance of Saliva Specimens for the Molecular Detection of SARS-CoV-2 in the Community Setting: Does Sample Collection Method Matter?
    Virology
    Performance of Saliva Specimens for the Molecular Detection of SARS-CoV-2 in the Community Setting: Does Sample Collection Method Matter?

    Data on the performance of saliva specimens for diagnosing coronavirus disease 2019 (COVID-19) in ambulatory patients are scarce and inconsistent. We assessed saliva-based specimens for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcriptase PCR (RT-PCR) in the community setting and compared three different collection methods.

    Marta Fernández-González, Vanesa Agulló, Alba de la Rica, Ana Infante, Mar Carvajal, José Alberto García, Nieves Gonzalo-Jiménez, Claudio Cuartero, Montserrat Ruiz-García, Carlos de Gregorio, Manuel Sánchez, Mar Masiá, Félix Gutiérrez
  • Free
    Evaluation of the Xpert Xpress SARS-CoV-2/Flu/RSV Assay for Simultaneous Detection of SARS-CoV-2, Influenza A and B Viruses, and Respiratory Syncytial Virus in Nasopharyngeal Specimens
    Virology
    Evaluation of the Xpert Xpress SARS-CoV-2/Flu/RSV Assay for Simultaneous Detection of SARS-CoV-2, Influenza A and B Viruses, and Respiratory Syncytial Virus in Nasopharyngeal Specimens

    Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A (flu A), influenza B (flu B), and respiratory syncytial virus (RSV) have overlapping clinical presentations, but the approaches to treatment and management of infections caused by these viruses are different. Therefore, rapid diagnosis in conjunction with infection prevention measures is important to prevent transmission of the diseases....

    Eddie Chi-man Leung, Viola Chi-ying Chow, May Kin-ping Lee, Kevin Pui-san Tang, Daniel Kwok-cheung Li, Raymond Wai-man Lai

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Journal of Clinical Microbiology® (JCM) publishes the most current research related to the laboratory diagnosis of human and animal infections and the role of the laboratory in both the management of infectious diseases and the elucidation of the epidemiology of infections.

Editor in Chief: Dr. Alexander J. McAdam

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